{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:52:13Z","timestamp":1757310733034,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a chronic inflammatory skin disease. Topical medicines are the preferred treatment for mild to moderate psoriasis, but the effect of excipients used in semi\u2010solid preparations on psoriasis\u2010like skin inflammation is not fully understood. In the present study, we investigated the effect of stearyl alcohol, a commonly used excipient, on imiquimod (IMQ)\u2010induced psoriasis\u2010like skin inflammation in mice. Psoriasis\u2010like skin inflammation was induced by topical IMQ treatment on the back of mice. Skin lesion severity was evaluated by using psoriasis area and severity index (PASI) scores. The skin sections were stained by haematoxylin\u2013eosin and immunohistochemistry. Stearyl alcohol (20% in vaseline) treatment significantly reduced the IMQ\u2010induced increase of PASI scores and epidermal thickness in mice. IMQ treatment increased the number of Ki67\u2010 and proliferating cell nuclear antigen (PCNA)\u2010positive cells in the skin, and the increases were inhibited by stearyl alcohol (20% in vaseline) treatment. Stearyl alcohol treatment (1%, 5%, 10% in vaseline) dose\u2010dependently ameliorated IMQ\u2010induced increase of PASI scores and epidermal thickness in mice. Hexadecanol (20% in vaseline), stearic acid (20% in vaseline) and vaseline treatment had no significant effect on IMQ\u2010induced psoriasis\u2010like skin inflammation in mice. In conclusion, stearyl alcohol has the effect of improving IMQ\u2010induced psoriasis\u2010like skin inflammation in mice.<\/jats:p>","DOI":"10.1111\/bcpt.13989","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T04:37:11Z","timestamp":1708490231000},"page":"498-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of stearyl alcohol on imiquimod\u2010induced psoriasis\u2010like skin inflammation in mice"],"prefix":"10.1111","volume":"134","author":[{"given":"Yu\u2010Hang","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Pharmacology China Pharmaceutical University  Nanjing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang\u2010Li","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology China Pharmaceutical University  Nanjing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui\u2010Miao","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pharmacology China Pharmaceutical University  Nanjing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Ji","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology China Pharmaceutical University  Nanjing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De\u2010Li","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology China Pharmaceutical University  Nanjing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7427-7358","authenticated-orcid":false,"given":"Zhi\u2010Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology China Pharmaceutical University  Nanjing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(07)61128\u20103"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20103386"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13101539"},{"issue":"6","key":"e_1_2_8_6_1","first-page":"679","article-title":"The topical vehicle as a key factor in the management of the psoriatic patients' therapy","volume":"148","author":"Vertuani S","year":"2013","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529\u20108019.2012.01458.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz9906"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac160"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.07.036"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2008.21.3.1203412"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1734"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802999"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2020.09.023"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2017.02.014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.08.027"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp\u20102020\u20100112"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065653"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106215"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.12.060"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010179"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111574"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12090789"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58070888"},{"key":"e_1_2_8_26_1","article-title":"Final report on the safety assessment of stearyl alcohol, oleyl alcohol, and octyl dodecanol","author":"Anon","year":"1985","journal-title":"J Ame Coll Toxicol"},{"key":"e_1_2_8_27_1","unstructured":"FDA 2023.Inactive ingredient search for approved drug products.https:\/\/www.accessdata.fda.gov\/scripts\/cder\/iig\/(accessed 18 August 2023)"}],"container-title":["Basic &amp; 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