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Therefore, we investigated the effects of antagonists with different affinities for \u03b1<jats:sub>1<\/jats:sub>\u2010AR subtypes on ejaculatory function and their mechanisms of action in normal rats. In the spontaneous seminal emission (SSE) test, systemically administered prazosin, terazosin, tamsulosin and naftopidil decreased the weight of ejaculated seminal material in a dose\u2010dependent manner; the potency order was as follows: tamsulosin &gt; terazosin &gt; prazosin &gt; naftopidil. The selective \u03b1<jats:sub>1D<\/jats:sub>\u2010AR antagonist BMY7378 had no effect on SSE. Intrathecal tamsulosin and naftopidil did not inhibit SSE. Tamsulosin, the most potent, was ineffective as a single dose and significantly increased seminal vesicle fluid in rats treated for 2\u00a0weeks but did not significantly change retrograde ejaculation. These results indicated that the difference in inhibitory potency of the five \u03b1<jats:sub>1<\/jats:sub>\u2010AR antagonists against SSE was due to the involvement of \u03b1<jats:sub>1A<\/jats:sub>\u2010AR subtypes. Our results further suggested that \u03b1<jats:sub>1<\/jats:sub>\u2010AR antagonist\u2010induced ejaculatory dysfunction at the peripheral level was mainly due to the loss of seminal emission, although some retrograde ejaculation may also be involved.<\/jats:p>","DOI":"10.1111\/bcpt.13993","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T03:24:17Z","timestamp":1709004257000},"page":"704-711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics of \u03b1<sub>1<\/sub>\u2010adrenoceptor antagonists\u2010induced ejaculatory dysfunction on spontaneous seminal emission in rats"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-2602","authenticated-orcid":false,"given":"Masaru","family":"Yoshizumi","sequence":"first","affiliation":[{"name":"Division of Physiology and Anatomy, Faculty of Pharmaceutical Sciences Tohoku Medical and 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