{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:02:47Z","timestamp":1783533767646,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009018","name":"Shanghai Municipal Human Resources and Social Security Bureau","doi-asserted-by":"publisher","award":["EK00000861"],"award-info":[{"award-number":["EK00000861"]}],"id":[{"id":"10.13039\/501100009018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pharmacological activity of oxcarbazepine (OXC) is primarily exerted through its active 10\u2010monohydroxy metabolite (MHD). Nonetheless, there is limited pharmacokinetic information available regarding paediatric patients with epilepsy treated with OXC, especially in infants and toddlers. Concurrently, this drug exhibits substantial variability in pharmacokinetics and therapeutic response across different individuals. We aimed to develop a model to quantitatively investigate factors that affect MHD pharmacokinetics to formulate a dosage guideline for OXC in Chinese paediatric patients. A total of 297 MHD trough concentrations were obtained from 287 epileptic children. Six body weight (BW)\u2010based allometric models were used for population pharmacokinetic modelling, while investigating the impact of other covariates on the apparent clearance. The one\u2010compartment model and age cut\u2010off model for the apparent clearance (CL\/F) were established to describe the pharmacokinetics of MHD. The probability to obtain target trough concentration ranges (TTCRs) of MHD between 3 and 35\u2009mg\/L was determined by Monte Carlo simulations for doses ranging from 8 to 90\u2009mg\/kg\/day. A new dose optimization strategy combining the dosage guidelines and Bayesian method provides a tailored approach for Chinese paediatric epileptic patients based on their individual BW and desired TTCRs of MHD, and also supports current dose recommendations, with the exception of children weighing \u22645\u00a0kg.<\/jats:p>","DOI":"10.1111\/bcpt.14000","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T11:44:11Z","timestamp":1710935051000},"page":"712-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Population pharmacokinetics of oxcarbazepine active metabolite in Chinese paediatric patients with epilepsy: Model\u2010based dose optimization"],"prefix":"10.1111","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7613-676X","authenticated-orcid":false,"given":"Wei","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010sheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010yong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010lin","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmiao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Children's Hospital of Fudan University, National Children's Medical Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_9_3_1","unstructured":"Full prescribing information. 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