{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:28:06Z","timestamp":1767162486410,"version":"build-2238731810"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","award":["L\u20102021\u201000089"],"award-info":[{"award-number":["L\u20102021\u201000089"]}],"id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","award":["L\u20102021\u201000089"],"award-info":[{"award-number":["L\u20102021\u201000089"]}],"id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008397","name":"Velux Fonden","doi-asserted-by":"publisher","award":["00034178"],"award-info":[{"award-number":["00034178"]}],"id":[{"id":"10.13039\/100008397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008397","name":"Velux Fonden","doi-asserted-by":"publisher","award":["00034178"],"award-info":[{"award-number":["00034178"]}],"id":[{"id":"10.13039\/100008397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aging is often associated with an increasing number of comorbidities that warrant use of multiple drugs which increases the use of potentially inappropriate medications (PIMs), drug\u2013drug interactions (DDIs) and drug\u2010related problems (DRPs). The aim is to assess the prevalence of polypharmacy, PIMs, DDIs and DRPs among Faroese residents aged \u226590\u2009years. In this population\u2010based cross\u2010sectional study, 494 individuals \u226590\u2009years were invited and 298 (60%) participated. A pharmacist\u2010led medication review was performed based on self\u2010information, electronic patient journal and the Faroese Prescription Registry. The prevalence of polypharmacy was 74% with no sex\u2010difference. Approximately 60% of participants used PIMs, primarily benzodiazepines and proton pump inhibitors, the latter being a frequently implicated medication in DRPs. Opioid use was low compared with other Nordic studies. DRPs were observed for 79% with discrepancies in the medication lists as the most common cause, and DDIs were identified for 47% of participants, mostly moderately clinically relevant DDIs. In conclusion, the medication use among the oldest old Faroese resembled that in other Nordic countries with a high prevalence of polypharmacy and use of PIMs, especially PPIs and benzodiazepines. However, no sex\u2010difference was noted in medication use and the use of opioids was low.<\/jats:p>","DOI":"10.1111\/bcpt.14012","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T20:48:45Z","timestamp":1713905325000},"page":"833-845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Medication use among the oldest old in the Faroe Islands\u2014A national cross\u2010sectional study"],"prefix":"10.1111","volume":"134","author":[{"given":"Beinta","family":"Joensen","sequence":"first","affiliation":[{"name":"Department of Research the National Hospital of the Faroe Islands  T\u00f3rshavn Faroe Islands"},{"name":"Chief Pharmaceutical Officer Office  T\u00f3rshavn Faroe Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunrit","family":"Niklasd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Department of Research the National Hospital of the Faroe Islands  T\u00f3rshavn Faroe Islands"},{"name":"Faculty of Health Sciences University of the Faroe Islands  T\u00f3rshavn Faroe Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Joensen","sequence":"additional","affiliation":[{"name":"Chief Pharmaceutical Officer Office  T\u00f3rshavn Faroe Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaare","family":"Christensen","sequence":"additional","affiliation":[{"name":"Epidemiology, Biostatistics and Biodemography Team, Department of Public Health University of Southern Denmark  Odense Denmark"},{"name":"The Danish Aging Research Center, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-8440","authenticated-orcid":false,"given":"Maria Skaalum","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Research the National Hospital of the Faroe Islands  T\u00f3rshavn Faroe Islands"},{"name":"Faculty of Health Sciences University of the Faroe Islands  T\u00f3rshavn Faroe Islands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2013.827660"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2018.1546841"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f7033"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/aft031"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875\u2010018\u20100795\u20105"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15419"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14416"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afr144"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S153458"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2015.03.003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.06.011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010022\u201003706\u2010z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18372"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.26910"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000260"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.CON.0000429172.27815.3f"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2007.11.007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jep.12547"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010019\u20101052\u2010z"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096\u2010015\u20100199\u20108"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096\u2010017\u20100581\u20109"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12140"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008986.pub2"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312116652568"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2016.08.005"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12351"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009095.pub3"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14101"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2165\/0002512\u2010200926010\u201000003"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/cky133"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/23337214231167980"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.11.1348"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2020.02.005"},{"key":"e_1_2_8_35_1","unstructured":"Sundhedsstyrelsen.Seponeringslisten. Sundhedsstyrelsen. 2021 2022.https:\/\/app.magicapp.org\/#\/guideline\/5773"},{"key":"e_1_2_8_36_1","unstructured":"Definition of drug\u2010related problem. Pharmaceutical Care Network Europe. Accessed Nov 2023.https:\/\/www.pcne.org\/working-groups\/2\/drug-related-problems"},{"key":"e_1_2_8_37_1","unstructured":"L\u00e6gemiddelstyrelsen.Interaktionsdatabasen. L\u00e6gemiddelstyrelsen2021 2022.http:\/\/www.interaktionsdatabasen.dk\/Default.aspx"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2020.1697676"},{"key":"e_1_2_8_39_1","unstructured":"Europe PCN.PCNE Classification for Drug\u2010Related Problems V9.1. Pharmaceutical Care Network Europe. Accessed 2021 2022 2023.https:\/\/www.pcne.org\/upload\/files\/417_PCNE_classification_V9-1_final.pdf"},{"key":"e_1_2_8_40_1","unstructured":"KluwerW.UpToDate. Accessed June 2023.https:\/\/www.uptodate.com"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/20420986221103918"},{"issue":"6","key":"e_1_2_8_43_1","article-title":"Prevalence of polypharmacy in Denmark","volume":"67","author":"Kornholt J","year":"2020","journal-title":"Dan Med J"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00326"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.2144\/fsoa\u20102020\u20100039"},{"key":"e_1_2_8_46_1","unstructured":"Statistics NHaW.[MED15] M01A N02A N02B: Sales of analgesics including anti\u2010inflammatory agents DDD\/1000 inhabitants\/Day by ATC\u2010code Year and Country. Accessed 23. Dec 2023.https:\/\/pxweb.nhwstat.org\/Prod\/pxweb\/en\/NHWSTAT\/NHWSTAT__Health__Pharmaceuticalproducts__Medicines%20consumption__Sales\/med15.px\/"},{"key":"e_1_2_8_47_1","unstructured":"(NHWStat) NHaWS.The opioid epidemic \u2013 the situation in the Nordic countrie. Nordic Medico\u2010Statistical Committee (NOMESCO). Accessed 4. Dec 2023.https:\/\/nhwstat.org\/health\/thematic-articles-health\/use-addictive-medicine"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/349584"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/ppar\/prad021"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M147"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264332"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12615"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010019\u201002669\u20102"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy241"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0250567"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268\u2010017\u20100207\u20107"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12594"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.48557"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283x16650156"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18001"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2013.06.001"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13477"},{"issue":"5","key":"e_1_2_8_63_1","first-page":"354","article-title":"Deprescribing proton pump inhibitors: evidence\u2010based clinical practice guideline","volume":"63","author":"Farrell B","year":"2017","journal-title":"Can Fam Physician"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894\u2010019\u20100732\u20103"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.467"}],"updated-by":[{"DOI":"10.1111\/bcpt.14048","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000}}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.14012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T04:20:19Z","timestamp":1715919619000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.14012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/bcpt.14012"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.14012","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,23]]},"assertion":[{"value":"2024-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}