{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:45:04Z","timestamp":1747183504689,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To investigate the in vitro effect of diclofenac on tubal smooth muscle as an alternative to hyoscine\u2010<jats:italic>N<\/jats:italic>\u2010butyl bromide, which is used for premedication before hysterosalpingography (HSG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Fallopian tubes were retrieved from seven healthy women after bilateral tubal ligation and in vitro contractility and histological studies were conducted using tissue bath and immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diclofenac sodium and hyoscine\u2010<jats:italic>N<\/jats:italic>\u2010butyl bromide did not significantly change the basal mean tension; however, they decreased the contractions induced by potassium chloride (KCl). The relaxant effect of diclofenac sodium and hyoscine\u2010<jats:italic>N<\/jats:italic>\u2010butyl bromide was not statistically significantly different. The presence of cyclooxygenase (COX)\u20102 enzyme in the fallopian tube was demonstrated by immunohistochemical studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The in vitro relaxant effect of diclofenac sodium on the fallopian tube is similar to hyoscine\u2010<jats:italic>N<\/jats:italic>\u2010butyl bromide. Diclofenac may have the potential to be used as an alternative to hyoscine\u2010<jats:italic>N<\/jats:italic>\u2010butyl bromide in premedication in HSG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcpt.14038","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T06:00:00Z","timestamp":1716876000000},"page":"173-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In vitro effect of hyoscine\u2010<i>N<\/i>\u2010butyl bromide and diclofenac sodium in human tuba uterina"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9129-4336","authenticated-orcid":false,"given":"Mustafa","family":"Sengul","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Izmir Katip Celebi University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baris","family":"Karadas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Izmir Katip Celebi University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selin","family":"Acar\u2010Sahan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Izmir Katip Celebi University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozan","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Izmir Katip Celebi University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Izmir Katip Celebi University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Simsek","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Izmir Katip Celebi University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tijen","family":"Kaya\u2010Temiz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Izmir Katip Celebi University Faculty of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.30990"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2009.28.12.1671"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.295095047"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.03.019"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244\u2010012\u20100183\u2010y"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2018.03.034"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.34171\/mjiri.33.31"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/gyn.1989.5.3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.12.3053"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002\u2010020199"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gal058"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/b:urol.0000025618.68752.5b"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00608"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0306\u20103623(97)00089\u2010x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20736"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den260"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090\u20106980(79)90079\u20100"}],"container-title":["Basic &amp; 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