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In this study, utilizing a mouse model of daily single dose of N\u2010acetylcysteine administration, we investigated the impact of this adjuvant on the treatment with atropine and\/or obidoxime as well as oxidative stress response in pyrimiphos\u2010methyl\u2010induced toxicity. We found that N\u2010acetylcysteine significantly reduces the oxidative stress generated by pyrimiphos\u2010methyl. The therapy consisting of atropine and\/or obidoxime routinely used in organophosphorous insecticide poisonings, including pyrimiphos\u2010methyl, had no effect on the antioxidant properties of N\u2010acetylcysteine. Adjunctive treatment offered by N\u2010acetylcysteine fills therapeutic gap and may provide the full potential against pyrimiphos\u2010methyl\u2010induced toxicity.<\/jats:p>","DOI":"10.1111\/bcpt.14044","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:38:15Z","timestamp":1718843895000},"page":"164-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["N\u2010acetylcysteine as a potentially safe adjuvant in the treatment of neurotoxicity due to pirimiphos\u2010methyl poisoning"],"prefix":"10.1111","volume":"135","author":[{"given":"Adamczuk","family":"Piotr","sequence":"first","affiliation":[{"name":"Department of Toxicology and Food Safety Institute of Rural Health  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamka","family":"Konrad","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Food Safety Institute of Rural Health  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojar","family":"Hubert","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Food Safety Institute of Rural Health  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukawski","family":"Krzysztof","sequence":"additional","affiliation":[{"name":"Department of Physiopathology Institute of Rural Health  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-5473","authenticated-orcid":false,"given":"Raszewski","family":"Grzegorz","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Food Safety Institute of Rural Health  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1603\/ME09286"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v22i1.68"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2019.1693589"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13115"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728220802517901"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12554"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201017900\u20101_151"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12784"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_9_11_1","unstructured":"Actellic 50ec. 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