{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:49:52Z","timestamp":1791589792116,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R288\u20102018\u2010380"],"award-info":[{"award-number":["R288\u20102018\u2010380"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF20SA0064340"],"award-info":[{"award-number":["NNF20SA0064340"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Soluble urokinase plasminogen activator receptor (suPAR) is a marker of systemic chronic inflammation. Elevated suPAR levels are associated with adverse clinical outcomes, but a small subset of patients with low suPAR also experience poor outcomes. Therefore, we aimed to characterize patients presenting to the emergency department with low suPAR (&lt;3\u2009ng\/mL) who died within 90\u2009days after discharge in a registry\u2010based study. Compared to patients with low suPAR who survived (n\u2009=\u200915\u2009122), those who died within 90\u2009days (n\u2009=\u200987) had higher age (75.4\u2009years), higher medication use (7.0; 71.3% with polypharmacy) and more blood tests outside reference intervals (5.0) (including C\u2010reactive protein, neutrophils and albumin), and the most common diagnoses were chronic pulmonary disease (27.6%), cerebrovascular disease (18.4%) and dementia (11.5%). Patients with low suPAR were more morbid than what was reflected by suPAR alone. Future studies must determine which factors that contribute the most to potential algorithms when stratifying patients based on their risk of adverse clinical outcomes. These data indicate that inclusion of medication data could be relevant.<\/jats:p>","DOI":"10.1111\/bcpt.14050","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T07:24:41Z","timestamp":1720682681000},"page":"364-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A characterization of patients with low soluble urokinase plasminogen activator receptor who died within 90\u2009days of hospital discharge"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8954-2675","authenticated-orcid":false,"given":"Louise Westberg Strejby","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"},{"name":"The Capital Region Pharmacy  Herlev Denmark"},{"name":"Department of Drug Design and Pharmacology University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-9257","authenticated-orcid":false,"given":"Esben","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aino Leegaard","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Byriel","family":"Walls","sequence":"additional","affiliation":[{"name":"The Capital Region Pharmacy  Herlev Denmark"},{"name":"Department of Drug Design and Pharmacology University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line Jee Hartmann","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"},{"name":"Department of Psychology and Neuroscience Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ove","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Emergency Department Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kallemose","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4058-3012","authenticated-orcid":false,"given":"Morten Baltzer","family":"Houlind","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"},{"name":"The Capital Region Pharmacy  Herlev Denmark"},{"name":"Department of Drug Design and Pharmacology University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.780641"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed\u20102015\u2010205444"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121\u2010020\u201000301\u2010w"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010018\u20100803\u20102"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506362"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00339"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003305"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010013\u20102914\u20100"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140052"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2020.11.051"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14982"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11434"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq433"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2017.04.005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010017\u20100434\u20103"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw213"},{"key":"e_1_2_10_20_1","unstructured":"BergCL BlixHS DansieLS IlicM SkoufaII LitleskareI SharikabadMN OlsenK SommerschildHT GranumT.Guidelines for ATC classification and DDD assignment.2022.https:\/\/www.whocc.no\/filearchive\/publications\/2022_guidelines_web.pdf"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110555"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201072377\u2010w"},{"key":"e_1_2_10_23_1","unstructured":"R Core.R: a language and environment for statistical computing. R Foundation for Statistical Computing Vienna Austria.2021.https:\/\/www.r-project.org\/"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109681(87)90171\u20108"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.29252\/beat\u2010070401"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010015\u20101974\u20100"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12600"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096\u2010014\u20109940\u2010y"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S353398"},{"key":"e_1_2_10_30_1","article-title":"Overall and inter\u2010individual effect of four different drug classes on soluble urokinase plasminogen activator receptor in type 1 and type 2 diabetes","author":"Curovic VR, Houlind MB","year":"2023","journal-title":"Diabetes Obes Metab"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.03.030"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1806\u201037562017000000151"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146678"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924\u2010977X(99)00062\u20100"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2298\/VSP140526016S"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa178"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979\u2010018\u20100141\u20108"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5415"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010019\u201002795\u2010x"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz058"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.14050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T02:30:00Z","timestamp":1724293800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.14050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,11]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/bcpt.14050"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.14050","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,11]]},"assertion":[{"value":"2024-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}