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Twenty healthy male participants (mean age 24 [range 20\u201331] years) were included. Tramadol (extended\u2010release formulation, 200\u2009mg\/day) or placebo was administered for 10\u00a0days in two study periods separated by 3\u00a0weeks. Gastrointestinal transit times and segmental volume, motility and water content were investigated with the 3D\u2010transit system and magnetic resonance imaging. Bowel movements and gastrointestinal symptoms were recorded daily. Tramadol prolonged colonic transit time (34\u2009h vs. 25\u2009h, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) and increased small bowel motility (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01) and water content (<jats:italic>p<\/jats:italic>\u00a0=\u20090.002) compared to placebo. Across all days of treatment, tramadol reduced the number of mean daily bowel movements (<jats:italic>p<\/jats:italic>\u00a0=\u20090.001) and increased mean stool consistency (<jats:italic>p<\/jats:italic>\u00a0=\u20090.006). Gastrointestinal symptom scores increased with tramadol (indigestion: +358%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.01; constipation: +475%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.01). Additionally, more participants fulfilled the diagnostic criteria for constipation after tramadol treatment compared to placebo (40% vs. 0%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). This study showed that tramadol treatment is associated with OIBD, and management of constipation and other bowel symptoms should, therefore, be prioritised when treating pain patients with tramadol.<\/jats:p>","DOI":"10.1111\/bcpt.14067","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T03:12:53Z","timestamp":1724296373000},"page":"475-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The influence of tramadol on bowel function: A randomised, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"135","author":[{"given":"Isabelle M.","family":"Larsen","sequence":"first","affiliation":[{"name":"Mech\u2010Sense, Department of Gastroenterology and Hepatology Aalborg University Hospital  Aalborg 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