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This study aimed to investigate the functional inhibitory effects of 60 medications, classified as anticholinergic burden scales 3 and 2 by the anticholinergic burden scale, on muscarinic receptor\u2010mediated contractions in the bladder and ileum.<\/jats:p><jats:p>The relaxation response induced by these drugs on isolated rat bladders and ileum smooth muscles constricted by carbachol was assessed using the organ bath method. All drugs inhibited smooth muscle contractile responses induced by the muscarinic receptor activation in a concentration\u2010dependent manner in the rat bladder and ileum. Notably, variations were observed in the relaxation responses of the drugs, and the function EC<jats:sub>50<\/jats:sub> values were positively correlated with the binding IC<jats:sub>50<\/jats:sub> values in the bladder and ileum.<\/jats:p><jats:p>The results of this study provide functional pharmacological evidence for the muscarinic receptor binding\u2010based anticholinergic burden scale. Implementation of this scale may help reduce the risk of constipation and urinary retention, which are common side effects associated with anticholinergic drugs.<\/jats:p>","DOI":"10.1111\/bcpt.14071","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T06:15:44Z","timestamp":1725257744000},"page":"451-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Functional anticholinergic activity of drugs classified as strong and moderate on the anticholinergic burden scale on bladder and ileum"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2044-5552","authenticated-orcid":false,"given":"Satomi","family":"Kagota","sequence":"first","affiliation":[{"name":"Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences Mukogawa Women's University  Nishinomiya Japan"},{"name":"Institute for Bioscience Mukogawa Women's University  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