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A two\u2010compartment model\u2014adjusted for body weight impact on clearances and volumes of distributions and scaled to the power of 0.75 and 1.0, respectively\u2014was found to adequately describe the paediatric pharmacokinetic data. The simulated population showed overlap in area under the plasma concentration\u2013time curve and maximum plasma concentration between the paediatric and adult populations, with paediatric exposures within 10%\u201315% above adult levels on average. To provide comparable exposure to the approved adult doses, weight\u2010based dosing adjustments are recommended for paediatric patients weighing \u226440\u2009kg, while no adjustments are needed for patients weighing &gt;40\u2009kg. These results support the dosing strategy being used in the ongoing efficacy and safety studies with eptinezumab in children and adolescents with migraine.<\/jats:p>","DOI":"10.1111\/bcpt.14076","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T08:39:15Z","timestamp":1724920755000},"page":"512-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Population pharmacokinetics of eptinezumab in paediatric patients with migraine and dose selection for phase 3 paediatric migraine studies"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9767-9643","authenticated-orcid":false,"given":"Johan","family":"Areberg","sequence":"first","affiliation":[{"name":"H. Lundbeck A\/S  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Rosen","sequence":"additional","affiliation":[{"name":"H. 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