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Thirty\u2010two female Wistar Albino rats were randomly allocated into four groups: control group, LPS group, LPS\u2009+\u2009DPG group and DPG group. At the end of the experimental phase, ovary, fallopian tube and uterus tissues were collected for histopathological, immunohistochemical, genetic and biochemical analyses. The findings showed that LPS caused histopathological changes characterized by marked hyperaemia, mild to moderate haemorrhage, oedema and neutrophil leucocyte infiltrations and degenerative and necrotic changes in the female genital tract. In addition, it decreased total antioxidant status (TAS), increased total oxidant status (TOS) and oxidative stress index (OSI) levels. LPS also increased the expressions of Cas\u20103, G\u2010CSF and IL\u20101\u03b2 in the ovary, fallopian tubes and uterus immunohistochemically. While Claudin\u20101 expression decreased, NLRP3 and AQP4 gene expressions increased due to LPS. However, DPG treatment prevented all these changes. The results of this study indicate that, DPG can be used to prevent LPS\u2010induced lesions in the female reproductive system.<\/jats:p>","DOI":"10.1111\/bcpt.14077","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T07:39:03Z","timestamp":1725521943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dapagliflozin prevents reproductive damage caused by acute systemic inflammation through antioxidant, anti\u2010inflammatory, and antiapoptotic mechanisms"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4575-5653","authenticated-orcid":false,"given":"Senay","family":"Topsakal","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Endocrinology and Metabolism Pamukkale University  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