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It is found that ISO intervention significantly reduced the ADH activity in liver tissue by using visible spectrophotometry, inhibited the in vivo metabolism of EG by using gas chromatography, lowered the levels of toxic metabolites glycolic acid and oxalic acid by using high\u2010performance liquid chromatography and decreased the expression of kidney injury markers serum creatinine (sCr), KIM\u20101, neutrophil gelatinase\u2010associated lipocalin (NGAL) and liver fatty acid\u2010binding protein (L\u2010FABP) by ELISA. Additionally, Western blotting results showed that ISO down\u2010regulated the expression of apoptotic factors Bax and cleaved caspase\u20103 in the kidneys and upregulated the expression of antiapoptotic factor Bcl\u20102. Pizzolato staining and polarized light microscopy results revealed the reduced deposition of calcium oxalate crystals in the kidney tubules. Using haematoxylin and eosin (H&amp;E), periodic acid\u2010Schiff (PAS) and Masson staining, we found attenuated kidney tissue pathological injury. Finally, ISO significantly reduced the mortality rate. In conclusion, ISO has the potential to be a valuable drug for the treatment of EG poisoning\u2010induced acute kidney injury.<\/jats:p>","DOI":"10.1111\/bcpt.14084","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T09:18:45Z","timestamp":1727342325000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Isovaleramide attenuates ethylene glycol poisoning\u2010induced acute kidney injury and reduces mortality by inhibiting alcohol dehydrogenase activity in rats"],"prefix":"10.1111","author":[{"given":"Kai","family":"Yang","sequence":"first","affiliation":[{"name":"Center of Emergency and Trauma The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Emergency and Trauma The First Affiliated Hospital of Xinjiang Medical 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