{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:09:56Z","timestamp":1787314196732,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/rationale<\/jats:title>\n                    <jats:p>Weekly cholecalciferol can replace daily supplementation to reduce pill burden in patients with complex medication regimens and hypovitaminosis D, but evidence supporting this switch is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to determine whether weekly cholecalciferol was superior to daily cholecalciferol to replete patients with hypovitaminosis D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a systematic review of randomized controlled trials involving participants with baseline hypovitaminosis D (&lt;30\u2009ng\/ml) comparing weekly\n                      <jats:italic>versus<\/jats:italic>\n                      daily cholecalciferol dosing and where serum cholecalciferol was measured within 120\u2009days of starting treatment. We searched MEDLINE, CINAHL and EMBASE from inception to 7 May 2024. A random\u2010effects meta\u2010analysis evaluated the odds ratio for repletion of serum vitamin D levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Eight trials involving 542 patients were included in the analysis. Weekly and daily cholecalciferol were not significantly different in correcting hypovitaminosis D (OR\u2009=\u20091.5, 95% CI\u2009=\u20090.3\u20136.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.6, favouring weekly dosing,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u200985.3%). A sensitivity analysis excluding otherwise healthy patients had similar findings (OR\u2009=\u20090.8, 95% CI\u2009=\u20090.3\u20132.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.6). Most studies were at risk of bias; the different doses being compared increased the heterogeneity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Limited direct evidence supports a switch from daily to weekly cholecalciferol dosing; however, weekly supplementation was not demonstrably worse at repleting levels and decreased a patient's daily pill burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcpt.14092","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T21:53:06Z","timestamp":1728856386000},"page":"685-692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of weekly\n                    <i>versus<\/i>\n                    daily cholecalciferol for repleting serum vitamin D (25(OH)D) deficiency: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4926-5195","authenticated-orcid":false,"given":"\u00c9milie","family":"Bortolussi\u2010Courval","sequence":"first","affiliation":[{"name":"Division of Clinical and Translational Research, Faculty of Medicine and Health Sciences McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Prosty","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Health Sciences McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Clinical and Translational Research, Faculty of Medicine and Health Sciences McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Leslie Dan Faculty of Pharmacy University of Toronto  Toronto Ontario Canada"},{"name":"Institute for Better Health Trillium Health Partners  Mississauga Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily G.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Division of Clinical and Translational Research, Faculty of Medicine and Health Sciences McGill University  Montreal Quebec Canada"},{"name":"Department of Medicine, Faculty of Medicine and Health Sciences McGill University  Montreal Quebec Canada"},{"name":"Clinical Practice Assessment Unit, Division of Internal Medicine McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Clinical and Translational Research, Faculty of Medicine and Health Sciences McGill University  Montreal Quebec Canada"},{"name":"Department of Medicine, Faculty of Medicine and Health Sciences McGill University  Montreal Quebec Canada"},{"name":"Division of Internal Medicine and Infectious Diseases, Department of Medicine, Faculty of Medicine and Health Sciences McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.2.332"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430\u2010020\u201000706\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010016\u20101137\u20109"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.08.019"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.02.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_8_1","volume-title":"Elicit: the AI research assistant","year":"2023"},{"key":"e_1_2_10_9_1","unstructured":"Covidence Systematic Review Software.Veritas Health Innovation;2024. 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