{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:39:31Z","timestamp":1787495971170,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Quercetin is known to reduce blood pressure (BP); however, its acute effects are unclear. We investigated the acute effects of quercetin on BP, aortic mechanical properties and vascular reactivity in female Sprague\u2013Dawley (SD) rats. Hypertension was induced using L\u2010NAME (40\u2009mg\/kg\/day). Quercetin (4.5\u00a0mg\/kg) was administered intravenously. Mechanical properties of the aortae were measured by echo\u2010tracking in normotensive and hypertensive rats. L\u2010NAME and quercetin quantities in the aorta were determined using AP\u2010MALDI\u2010MSI. Vascular reactivity was performed in mesenteric and renal arteries. L\u2010NAME increased BP and PWV\u03b2 while decreasing strain. Quercetin decreased BP and ameliorated PWV\u03b2 in L\u2010NAME\u2010induced hypertensive rats. Ex vivo, the acetylcholine (ACh)\u2010induced increase in tension at 100\u2009\u03bcM was reduced in renal arteries when exposed to quercetin while phenylephrine (Phe)\u2010induced contractile response was augmented. In quiescent rings of renal arteries incubated with L\u2010NAME (10\u00a0\u03bcM) and TRAM\u201034 (1\u00a0\u03bcM), the ACh\u2010induced vasoconstrictions were inhibited by quercetin. Quercetin resulted in concentration\u2010dependent vasodilation in mesenteric arteries and increased its sensitivity to ACh\u2010induced relaxations. Quercetin lowered BP in L\u2010NAME\u2010induced hypertensive rats, likely due to changes in aortic mechanical properties and relaxation of resistance arteries. Further research is warranted to clarify the acute effects of quercetin on renal arteries in this hypertensive model.<\/jats:p>","DOI":"10.1111\/bcpt.14113","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T02:15:08Z","timestamp":1734660908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Decreased blood pressure with acute administration of quercetin in L\u2010NAME\u2010induced hypertensive rats"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8351-6891","authenticated-orcid":false,"given":"Siluleko A.","family":"Mkhize","sequence":"first","affiliation":[{"name":"Wits Integrated Molecular Physiology Research Initiative, Wits Health Consortium, School of Physiology, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5161-5932","authenticated-orcid":false,"given":"Refentshe A.","family":"Nthlane","sequence":"additional","affiliation":[{"name":"Wits Integrated Molecular Physiology Research Initiative, Wits Health Consortium, School of Physiology, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5886-8131","authenticated-orcid":false,"given":"Sanelisiwe P.","family":"Xhakaza","sequence":"additional","affiliation":[{"name":"Wits Integrated Molecular Physiology Research Initiative, Wits Health Consortium, School of Physiology, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-087X","authenticated-orcid":false,"given":"Peter D.","family":"Verhaert","sequence":"additional","affiliation":[{"name":"ProteoFormiX BV  Vorselaar Belgium"},{"name":"Department of Imaging and Pathology, Faculty of Medicine Katholieke Universiteit Leuven  Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-1779","authenticated-orcid":false,"given":"Sooraj","family":"Baijnath","sequence":"additional","affiliation":[{"name":"Wits Integrated Molecular Physiology Research Initiative, Wits Health Consortium, School of Physiology, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-7336","authenticated-orcid":false,"given":"Aletta M. 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