{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:48:21Z","timestamp":1770972501463,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The COVID\u201019 pandemic may have increased anticoagulant initiation due to the thrombogenic nature of the disease or decreased due to the societal impact of the pandemic. We aimed to study the effect of the COVID\u201019 pandemic on initiation of anticoagulants in Sweden. We conducted a single interrupted time series analysis on the monthly cumulative incidence of nonvitamin K antagonist oral anticoagulants (NOAC), warfarin, or heparins, before and after March 2020, using SCIFI\u2010PEARL dataset. For anticoagulants in total, there were no statistically significant changes or differences in the trends of initiation after the start of the pandemic. There was a slight numerical decrease in initiation after the onset of the pandemic, particularly for NOACs. For individuals aged \u2265 65\u2009years, however, the immediate decrease in initiation was considerable for NOACs. The prepandemic declining trend of warfarin initiation seemed to attenuate, that is, became less negative, after March 2020. We did not find any profound effect of the COVID\u201019 pandemic on the initiation of anticoagulants in total. However, among individuals aged \u2265 65\u2009years, a notable immediate decrease in initiation of NOACs was observed. Furthermore, the onset of the pandemic may have attenuated the downward temporal trend in initiation of warfarin use.<\/jats:p>","DOI":"10.1111\/bcpt.14119","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T04:33:17Z","timestamp":1736137997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Initiation of Anticoagulants During the COVID\u201019 Pandemic in Sweden: An Interrupted Time Series Analysis"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7484-7488","authenticated-orcid":false,"given":"Per\u2010Jostein","family":"Samuelsen","sequence":"first","affiliation":[{"name":"Regional Medicines Information and Pharmacovigilance Centre (RELIS) University Hospital of North Norway  Tromso Norway"},{"name":"Pharmacoepidemiology, Department of Pharmacy Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0531-2516","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Wettermark","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology, Department of Pharmacy Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-5668","authenticated-orcid":false,"given":"Fredrik","family":"Nyberg","sequence":"additional","affiliation":[{"name":"School of Public Health and Community Medicine, Institute of Medicine Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8118-4988","authenticated-orcid":false,"given":"Mohammadhossein","family":"Hajiebrahimi","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology, Department of Pharmacy Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","unstructured":"A.CukerCOVID\u201019: Hypercoagulability \u2013 UpToDate 2024 accessed December 5 2024.https:\/\/www.uptodate.com\/contents\/covid\u201019\u2010hypercoagulability.","DOI":"10.1097\/01.NPR.0000000000000237"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102021\u2010069590"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16535"},{"key":"e_1_2_11_5_1","unstructured":"Socialstyrelsen.Covid\u201019. 2024 accessed December 6 2024 https:\/\/www.folkhalsorapportstockholm.se\/rapporten2\/sjukdomar\u2010och\u2010skador\/covid\u201019\/."},{"key":"e_1_2_11_6_1","unstructured":"N.BeechingCoronavirus Disease 2019 (COVID\u201019) \u2010 Symptoms Diagnosis and treatment |BMJ Best Practice accessed January 31 2023 https:\/\/bestpractice.bmj.com\/topics\/en\u2010gb\/3000201?q=Coronavirus%20disease%202019%20(COVID\u201019."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102021\u2010059130"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/23969873231204127"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010023\u201000967\u20109"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S312742"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2807\/esm.11.05.00626\u2010en"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102458\u201011\u2010450"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1294"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010017\u20100316\u20101"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010009\u20109350\u2010y"},{"key":"e_1_2_11_16_1","unstructured":"WHO ATC Center. 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