{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:54:24Z","timestamp":1781780064066,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The worldwide legalization of medicinal cannabis has led to an increased use of products made by commercial operators. These products often contain minor cannabinoids such as cannabinol (CBN) which are advertised to improve sleep. Products are also available in which CBN is combined with conventional therapies, with a common product containing both CBN and the widely used sleep\u2010aid melatonin. The combination of CBN and melatonin provides potential for a pharmacokinetic drug\u2013drug interaction (DDI) given that cannabinoids are known to inhibit drug\u2010metabolizing enzymes. Indeed, we recently reported that CBN potently inhibited the CYP1A2\u2010mediated metabolism of caffeine. CYP1A2 is the major hepatic enzyme involved in the metabolism of melatonin; thus, in this study, we aimed to examine whether CBN inhibited CYP1A2\u2010mediated metabolism of melatonin in\u00a0vitro and in\u00a0vivo. We found CBN potently inhibited CYP1A2\u2010mediated metabolism of melatonin and increased the apparent oral bioavailability of melatonin in mice with a four\u2010fold increase in the plasma melatonin exposure. Our results provide an additional example of a potential DDI involving melatonin.<\/jats:p>","DOI":"10.1111\/bcpt.14120","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T06:43:46Z","timestamp":1735195426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Preclinical Evidence for a Drug\u2013Drug Interaction Between Cannabinol and Melatonin"],"prefix":"10.1111","volume":"136","author":[{"given":"Lyndsey\u00a0L.","family":"Anderson","sequence":"first","affiliation":[{"name":"Brain and Mind Centre The University of Sydney  Sydney New South Wales Australia"},{"name":"Discipline of Pharmacology, School of Pharmacy, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Lambert Initiative for Cannabinoid Therapeutics The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole\u00a0A.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka\u00a0Lai","family":"Yip","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre The University of Sydney  Sydney New South Wales Australia"},{"name":"Discipline of Pharmacology, School of Pharmacy, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Lambert Initiative for Cannabinoid Therapeutics The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8843-9760","authenticated-orcid":false,"given":"Michael","family":"Udoh","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre The University of Sydney  Sydney New South Wales Australia"},{"name":"Discipline of Pharmacology, School of Pharmacy, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Lambert Initiative for Cannabinoid Therapeutics The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer\u00a0A.","family":"Kearney","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon\u00a0C.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre The University of Sydney  Sydney New South Wales Australia"},{"name":"Discipline of Pharmacology, School of Pharmacy, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Lambert Initiative for Cannabinoid Therapeutics The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2021.0006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/pha0000682"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010024\u201002018\u20107"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248\u2010021\u201000616\u20107"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.002410"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16355"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201094212\u20106"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010015\u20101873\u20104"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14193934"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088\u2010199427060\u201000004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014\u20102999(99)00673\u20101"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714\u2010200104000\u201000008"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345194"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13780"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.14120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T02:18:23Z","timestamp":1737339503000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.14120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,25]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/bcpt.14120"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.14120","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,25]]},"assertion":[{"value":"2024-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14120"}}