{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:49:15Z","timestamp":1790264955416,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Drug\u2010induced organ toxicity is a significant health concern, with gentamicin known for its effective antibacterial properties but also severe side effects, particularly cytotoxicity in liver and kidney tissues. This current study observed the preventive role of baicalein and bergenin against hepatic and renal injuries caused by gentamicin in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two male Sprague Dawley rats were divided into four groups, namely, control, gentamicin (gentamicin 80\u2009mg\/kg\/day), baicalein (gentamicin 80\u2009mg\/kg\/day\u2009+\u2009baicalein 100\u2009mg\/kg\/day) and bergenin (gentamicin 80\u2009mg\/kg\/day\u2009+\u2009bergenin 100\u2009mg\/kg\/day). Hepatotoxicity and nephrotoxicity were induced by giving gentamicin (80\u2009mg\/kg\/day). We evaluated the biochemical markers, including alkaline phosphatase (ALP), urea, alanine transaminase (ALT), creatinine and aspartate transaminase (AST) levels, antioxidant enzymes, oxidative stress parameters and histopathological and immunohistochemical changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gentamicin increased oxidative stress parameters and decreased antioxidant activity. The treatment with baicalein and bergenin significantly restored these markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Baicalein and bergenin significantly mitigated gentamicin\u2010induced hepatic and renal toxicity by restoring biochemical markers, reducing oxidative stress and enhancing antioxidant enzyme activity. Histopathological and immunohistochemical analyses confirmed the protective effects of both compounds against organ damage. No statistically significant differences were observed between the two drugs for these parameters. These results suggest their potential as therapeutic agents to prevent gentamicin\u2010induced organ toxicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcpt.14121","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T06:45:06Z","timestamp":1735281906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Protective Effects of Baicalein and Bergenin Against Gentamicin\u2010Induced Hepatic and Renal Injuries in Rats: An Immunohistochemical and Biochemical Study"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-3169","authenticated-orcid":false,"given":"Fazile\u00a0Nur","family":"Ekinci\u00a0Akdemir","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Science A\u011fr\u0131 \u0130brahim \u00c7e\u00e7en University  A\u011fr\u0131 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