{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:08Z","timestamp":1787013908077,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Paclitaxel (PAC), derived from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Taxus brevifolia<\/jats:italic>\n                    <\/jats:styled-content>\n                    , is used to treat solid tumours but causes reproductive toxicity due to oxidative stress, affecting sperm quality and testicular tissue. Nerolidol (NRL), an antioxidant sesquiterpene alcohol, has not been studied for its potential to reduce PAC\u2010induced reproductive damage. This study investigates NRL's ability to mitigate PAC\u2010induced reproductive toxicity in rats. Forty healthy adult male Spraque Dawley rats were randomly divided into four equal groups (Control, PAC, NRL, PAC\u2009+\u2009NRL). PAC was given intraperitoneally at a dose of 2\u2009mg\/kg once a week for 4\u2009weeks. NRL was given orally at a dose of 100\u2009mg\/kg\/day for 4\u2009weeks. Control group received PAC and NRL vehicles. After 4\u2009weeks, testis tissue samples were collected, and parameters, including oxidants, antioxidants, sperm motility, density, abnormal spermatozoon ratios and cytokines, were measured. PAC administration increased oxidant levels and decreased antioxidant enzyme activities. Nerolidol mitigated these alterations significantly. Similarly, PAC elevated IL\u20101, IL\u20106, TNF\u2010\u03b1 levels and lowered IL\u201010 levels, these effects attenuated by nerolidol in the PAC\u2009+\u2009NRL group. In conclusion, it was determined that PAC induces reproductive toxicity through oxidative stress, and NRL demonstrates potential in ameliorating these effects through its antioxidant activity.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.14126","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T04:20:07Z","timestamp":1737001207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Protective Effect of Nerolidol on Paclitaxel\u2010Induced Reproductive Toxicity in Rats: Oxidative Stress and Inflammation"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4625-7218","authenticated-orcid":false,"given":"\u0130dris","family":"Ayhan","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Pamukkale University  Denizli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5566-8321","authenticated-orcid":false,"given":"Nese\u00a0Basak","family":"Turkmen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3902-3210","authenticated-orcid":false,"given":"Asli","family":"Taslidere","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6494-9229","authenticated-orcid":false,"given":"Muhterem","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Obstetric and Gynecology, Faculty of Veterinary Medicine Firat University  Elaz\u0131g Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-3560","authenticated-orcid":false,"given":"Osman","family":"Ciftci","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Pamukkale University  Denizli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.6.5.609"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051309398"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/277665a0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.12067FP"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-009-0596-x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2013.852271"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13394"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1162"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajme.2017.09.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2017-0131"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1147414"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026614666141203120833"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21050529"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.10.3357-3360.2003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/12.1.151"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2007-7-812"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12166"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-013-1092-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121380"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110793"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1385\/0-89603-472-0:101"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(68)90092-4"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.3.497"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-091302-2.50032-3"},{"issue":"1","key":"e_1_2_8_27_1","first-page":"158","article-title":"Studies on the Quantitative and Qualitative Characterization of Erythrocyte Glutathione Peroxidase","volume":"70","author":"Paglia D. 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