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This study aims to evaluate the effectiveness of FLV in mitigating damage caused by lipopolysaccharide (LPS) to the female genital tract. Thirty\u2010two female Wistar Albino rats were randomly divided into four groups: control, LPS, LPS\u2010FLV and FLV. At the end of the experimental period, tissues from the ovaries, fallopian tubes and uterus were collected for histological, immunohistochemical and genetic analyses. Histological examination of the LPS group revealed mild to moderate bleeding, oedema and neutrophil infiltration. Additionally, there were signs of endometrial damage in the uterus and loss of cilia in the fallopian tubes. Immunohistochemical analysis showed that LPS increased the expressions of nuclear factor kappa beta (NF\u2010\u03baB) and cation\u2010dependent mannose 6\u2010phosphate receptors (CD\u2010MPR) and reduced kisspeptin\u20101 (KISS\u20101) expression. Genetic analysis indicated that LPS increased the expression of the NOD\u2010like receptor family pyrin domain\u2010containing 3 (NLRP3) and aquaporin4 (AQP4) genes while decreasing Claudin\u20101 expression. However, all these adverse effects were reversed by FLV treatment. The study's findings suggest that FLV may be beneficial in treating LPS\u2010induced damage to the female reproductive system.<\/jats:p>","DOI":"10.1111\/bcpt.70000","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T11:53:43Z","timestamp":1738410823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fluvoxamine Inhibited NLRP3 and NF\u2010\u03baB Inflammatory Pathways and Maintained Genital Functions by Ameliorating CD\u2010MPR, KISS\u20101, AQP4 and Claudin\u20101 Expressions"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4575-5653","authenticated-orcid":false,"given":"Senay","family":"Topsakal","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine Pamukkale University  Denizli 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