{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:04:35Z","timestamp":1778681075162,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Chlordiazepoxide is effective in treating alcohol withdrawal syndrome, but it poses a risk of long\u2010term sedation. The prevalence of this side effect and its risk factors remain uncertain. This retrospective cross\u2010sectional study aimed to estimate both using data from Aarhus University Hospital's BI portal. We identified and manually reviewed patient records from 1 September 2019 to 31 August 2021, including the treating physicians' conclusions on ICU admissions to determine whether they were likely due to chlordiazepoxide toxicity. Chlordiazepoxide was administered to 1363 unique patients in the study period. We identified 32 ICU admissions preceded by chlordiazepoxide administration, 5 of which (16%) were likely related to chlordiazepoxide toxicity. Patients with chlordiazepoxide\u2010induced admissions received higher cumulative doses compared to other admissions (425\u2009mg vs. 150\u2009mg, <jats:italic>p<\/jats:italic>\u2009=\u20090.01), had longer ICU stays (median 8 vs. 2\u2009days, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and required higher doses of flumazenil (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). Their median age was above 60\u2009years, and not all had known liver disease. The overall incidence of long\u2010term chlordiazepoxide toxicity was approximately 0.35%, with risk factors including higher doses and age above 60. Our findings suggest increased caution when treating not only patients with liver disease but also elderly patients with chlordiazepoxide for alcohol withdrawal symptoms.<\/jats:p>","DOI":"10.1111\/bcpt.70018","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T10:25:45Z","timestamp":1741775145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence of Patients Admitted to Intensive Care After Administration of Chlordiazepoxide in the Emergency Room"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0784-3206","authenticated-orcid":false,"given":"Jakob\u00a0N\u00f8rgaard","family":"Henriksen","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4409-9341","authenticated-orcid":false,"given":"Sara\u00a0Buttrup","family":"Rosenquist","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte\u00a0Goldb\u00e6kdal","family":"Illum","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0543-6519","authenticated-orcid":false,"given":"Charlotte\u00a0Uggerh\u00f8j","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Forensic Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/FAD.0000000000000068"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01064806"},{"key":"e_1_2_10_4_1","unstructured":"Danish Health Data Agency \u2010 Medicine Registry Denmark https:\/\/medstat.dk\/."},{"issue":"3","key":"e_1_2_10_5_1","article-title":"Benzodiazepines Should Still Be First\u2010Line Treatment for Alcohol Withdrawal","volume":"179","author":"Askgaard G.","year":"2017","journal-title":"Ugeskrift for Laeger"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.14.1513.31941"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13449"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/24734306.2024.2395699"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974\u20102700.145422"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq025"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001480"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563658909038575"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1979262240"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-824516-3.00009-4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-197803050-00004"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2007.00829.x"},{"key":"e_1_2_10_17_1","unstructured":"Aarhus University Hospital \u201cAbout \u201dhttps:\/\/www.fagperson.auh.dk\/om\u2010os\/fakta\/nogletal\/."},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","unstructured":"BCPT \u201cBCPT 2023 Policy for Experimental and Clinical Studies \u201d (2023) https:\/\/doi.org\/10.1111\/bcpt.13944.","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2021.11.004"},{"key":"e_1_2_10_21_1","unstructured":"WHO \u201cManagement of Alcohol Withdrawal \u2010 WHO Recommendations \u201d (2012) https:\/\/www.who.int\/teams\/mental\u2010health\u2010and\u2010substance\u2010use\/treatment\u2010care\/mental\u2010health\u2010gap\u2010action\u2010programme\/evidence\u2010centre\/alcohol\u2010use\u2010disorders\/management\u2010of\u2010alcohol\u2010withdrawal."}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T01:56:52Z","timestamp":1744250212000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.70018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,12]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/bcpt.70018"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.70018","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,12]]},"assertion":[{"value":"2024-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70018"}}