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Young ICR mice were administered montelukast continuously for 28\u2009days, and depression\u2010like behaviours were assessed using the open field test (OFT), tail suspension test (TST), and forced swim test (FST). Oxidative stress and inflammatory markers were analysed via RT\u2010qPCR, biochemical assays and western blot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results revealed that 24\u2009h post\u2010montelukast administration, cysteinyl leukotriene receptor 1 and malondialdehyde (MDA) levels were significantly upregulated in the hippocampus, while glutathione (GSH), glutathione peroxidase 4 (GPx4), superoxide dismutase 2 (SOD2) and catalase (CAT) levels were downregulated. After 28\u2009days of treatment, MDA levels remained elevated, and GSH, GPx4, SOD2 and CAT levels were further reduced. Additionally, hippocampal interleukin\u20101\u03b2 and serum corticosterone levels were increased, whereas hippocampal glucocorticoid receptor expression was decreased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings collectively demonstrate that montelukast induces depression\u2010like behaviours in young ICR mice through mechanisms involving enhanced oxidative stress and inflammatory responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcpt.70033","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T02:20:01Z","timestamp":1744338001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Montelukast Induces Depressive\u2010Like Behaviour in ICR Young Mice Through Oxidative Stress and Inflammatory Response"],"prefix":"10.1111","volume":"136","author":[{"given":"Shalawate","family":"Ayijiang","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murezati","family":"Tiliwaerde","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanlin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-0236","authenticated-orcid":false,"given":"Zengliang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199856020-00010"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.1609"},{"key":"e_1_2_11_4_1","unstructured":"Asthma. 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