{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:39:04Z","timestamp":1791545944174,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Hemiplegic shoulder pain (HSP) is a common post\u2010stroke complication impairing function and quality of life. Botulinum toxin A (BTA), a neurotoxin that inhibits acetylcholine release and reduces spasticity, has been proposed for treating HSP, though its clinical effectiveness remains unclear. This meta\u2010analysis aimed to evaluate BTA's efficacy in managing HSP. Nine randomized controlled trials involving 272 patients were included. Compared to placebo, BTA significantly reduced pain at 1\u2009week (SMD\u2009=\u2009\u22120.93; 95% CI [\u22121.67, \u22120.19]; <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and 4\u2009weeks (SMD\u2009=\u2009\u22120.90; 95% CI [\u22121.51, \u22120.28]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), but not at 12\u2009weeks. External rotation ROM improved at all time points, peaking at 4\u2009weeks (WMD\u2009=\u20096.20; 95% CI [3.11, 9.30]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Abduction ROM improved at 4 and 12\u2009weeks. Spasticity decreased significantly throughout, with the largest reduction at 12\u2009weeks (WMD\u2009=\u2009\u22120.78; 95% CI [\u22121.42, \u22120.14]; <jats:italic>p<\/jats:italic>\u2009=\u20090.02). Functional gains were noted at 4\u2009weeks. However, these results should be interpreted cautiously due to small samples and heterogeneous injection protocols across studies. In conclusion, BTA is effective for short\u2010term HSP management, particularly in relieving pain and improving motor function. Further large\u2010scale trials with standardized methods are needed.<\/jats:p>","DOI":"10.1111\/bcpt.70043","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T04:39:55Z","timestamp":1745901595000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness of Botulinum Toxin A Injection for Hemiplegic Shoulder Pain: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"136","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Zibo Central Hospital  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongge","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Zibo Central Hospital  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Zibo Central Hospital  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6927-5342","authenticated-orcid":false,"given":"Lichao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Zibo Central Hospital  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1191\/0269215503cr612oa"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3801(02)00055-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2013-000606"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2007.03.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000496"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e318214e976"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-1238"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/pmt-2018-0075"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins15080509"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03128.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2015.06.018"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2020.12.010"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1566-9_3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.128371"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215506072082"},{"issue":"6","key":"e_1_2_10_21_1","first-page":"534","article-title":"Clinical Study of the Effects of Botulinum Toxin Injection on Shoulder Pain Following Stroke Under Ultrasonography","volume":"38","author":"Ma X. 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