{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:55:32Z","timestamp":1793019332191,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study describes opioid and benzodiazepine poisonings in Denmark from 2014 to 2022. The analgesic effect of opioids and sedative effect of benzodiazepines are used to treat pain, insomnia and anxiety disorders and can cause abuse and addiction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective observational register study with data from the Danish Poison Information Centre with alprazolam, clonazepam, oxazepam, buprenorphine, diacetylmorphine, methadone, morphine, oxycodone and tramadol poisonings. Multiple recordings of the same exposure are only registered once.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Totally 10\u2009965 enquiries were included with a 55\/43% female\/male ratio (2% unaccounted). The number of enquiries regarding poisonings with alprazolam increased from 56 in 2014 to 289 in 2022 (+416%) or from 2.27 to 7.71 per 1000 enquiries to the DPIC (+240%). The corresponding numbers regarding the other eight substances were buprenorphine [22\/33 (+50%); 0.89\/0.88 (\u22121%)], morphine [125\/250 (+100%); 5.06\/6.67 (+32%)], oxazepam [240\/364 (+52%); 9.71\/9.71 (0%)], oxycodone [44\/199 (+352%); 1.78\/5.31 (+198%)], tramadol [262\/421 (+61%); 10.6\/11.23 (+6%)], methadone [65\/63 (\u22123%); 2.63\/1.68 (\u221236%)], clonazepam [60\/92 (+53%); 2.43\/2.45 (+1%)] and diacetylmorphine [17\/20 (+18%); 0.69\/0.53 (\u221223%)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our 9\u2010year study period, we observed large increases in poisonings with alprazolam and oxycodone. In the remaining drugs examined, we observed no change or even a reduction of the poisonings when adjusted for the general increase in enquiries to the DPIC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcpt.70044","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T04:23:34Z","timestamp":1746505414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Poisonings With Opioids and Benzodiazepines in Denmark: A Retrospective Study From the Danish Poison Information Centre"],"prefix":"10.1111","volume":"136","author":[{"given":"Alba\u00a0K.\u00a0V.","family":"Sigfredsson","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte\u00a0Fris","family":"Palmqvist","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5548-6381","authenticated-orcid":false,"given":"Kim","family":"Dalhoff","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010020\u201003016\u20106"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40801\u2010019\u201000163\u2010w"},{"key":"e_1_2_10_4_1","unstructured":"The Danish Health Authority \u201cF\u00e6rre personer er langtidsbrugere af st\u00e6rk smertestillende medicin \u201d The Danish Health Authority (2020) accessed January 9 2023 https:\/\/www.sst.dk\/da\/Nyheder\/2020\/Faerre\u2010personer\u2010er\u2010langtidsbrugere\u2010af\u2010staerk\u2010smertestillende\u2010medicin."},{"key":"e_1_2_10_5_1","unstructured":"The Danish Ministry of Health \u201cVejledning om ordination af afh\u00e6ngighedsskabende l\u00e6gemidler \u201d (2019) accessed January 9 2023 https:\/\/www.retsinformation.dk\/eli\/retsinfo\/2019\/9523."},{"key":"e_1_2_10_6_1","unstructured":"Klinisk Farmakologisk Afdeling and Medicinteamet \u201cPerorale opioider \u2013 undg\u00e5 de hurtigtvirkende til kroniske non\u2010maligne smerter \u201d (2019) accessed January 9 2023 https:\/\/farmakologi.au.dk\/fileadmin\/biomed.au.dk\/Farmakologi\/110071_mim\u2010informationspakke\u2010\u2010perorale\u2010opioider\u2010november\u20102019.pdf."},{"key":"e_1_2_10_7_1","unstructured":"The Danish Health Data Authority \u201cForbruget af opioider er aftaget efter \u00f8get fokus p\u00e5 brugen \u201d (2020) accessed January 9 2023 https:\/\/sundhedsdatastyrelsen.dk\/\u2010\/media\/sds\/filer\/find\u2010tal\u2010og\u2010analyser\/laegemidler\/smertestillende\u2010medicin\/forbrug_af_opioider_2019.pdf."},{"key":"e_1_2_10_8_1","unstructured":"Pro.medicin.dk \u201cDanish Pharmaceutical Information \u201d accessed January 9 2023 pro.medicin.dk."},{"key":"e_1_2_10_9_1","unstructured":"Unge og Rusmidler \u201cXanax: Kendt medicin i nye kl\u00e6der \u201d City of Copenhagen accessed January 9 2023 https:\/\/ungeogrusmidler.kk.dk\/vidensarbejde\/data\u2010og\u2010rapporter\/artikler\u2010om\u2010u\u2010turn\/xanax\u2010kendt\u2010medicin\u2010i\u2010nye\u2010klaeder."},{"key":"e_1_2_10_10_1","unstructured":"J. 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