{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T21:53:12Z","timestamp":1775339592878,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Antidepressant (<jats:sc>AD<\/jats:sc>) discontinuation in long\u2010term users can be challenging for both patients and healthcare providers (HCPs). Better understanding of how HCPs handle this challenge is needed to improve discontinuation care. Therefore, we identified <jats:sc>AD<\/jats:sc> discontinuation barriers and facilitators from the viewpoint of community pharmacists (CPs), general practitioners (GPs), psychiatrists and nurse practitioners and explored their views on their specific roles in <jats:sc>AD<\/jats:sc> discontinuation. Two focus group discussions involving four GPs, six pharmacists and three psychiatrists and one interview with a nurse practitioner were performed. Discussions were recorded and transcribed verbatim. Directed content analysis was performed using the theoretical domains framework. Six themes were identified: identification of patients, behaviour of HCPs regarding <jats:sc>AD<\/jats:sc> discontinuation, fears and emotions, context and resources, knowledge, evidence and skills and professional attitude. All HCPs stressed the importance of raising awareness for <jats:sc>AD<\/jats:sc> discontinuation. Barriers included fear of recurrence or discontinuation symptoms, poor collaboration between HCPs and lack of resources. Facilitators included the availability of tools and guidelines. HCPs were unaware and uncertain about each other's roles and responsibilities and showed motivation to provide guidance. This requires professional collaboration agreements and sufficient resources. Experienced CPs may contribute by identifying <jats:sc>AD<\/jats:sc> users and providing information\/support.<\/jats:p>","DOI":"10.1111\/bcpt.70051","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T09:40:38Z","timestamp":1748252438000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Healthcare Providers' Perspectives on Antidepressant Discontinuation: A Focus Group Study"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8095-5213","authenticated-orcid":false,"given":"S.","family":"Bouarfa","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacy Amsterdam University Medical Centre  Amsterdam the Netherlands"},{"name":"Amsterdam Public Health Research Institute  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma","family":"G\u00f6ttgens","sequence":"additional","affiliation":[{"name":"Department of Primary and Community Care, Radboud Institute of Health Sciences Radboud University Medical Centre  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne\u00a0A.","family":"Ligthart","sequence":"additional","affiliation":[{"name":"Department of Primary and Community Care, Radboud Institute of Health Sciences Radboud University Medical Centre  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto\u00a0R.","family":"Maarsingh","sequence":"additional","affiliation":[{"name":"Amsterdam Public Health Research Institute  Amsterdam the Netherlands"},{"name":"Department of General Practice Amsterdam University Medical Centre  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiaan\u00a0H.","family":"Vinkers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Department of Anatomy and Neurosciences Amsterdam University Medical Centre  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience (Mood, Anxiety, Psychosis, Stress and Sleep Program)  Amsterdam the Netherlands"},{"name":"Academic Working Place Depression, GGZ InGeest  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henricus\u00a0G.","family":"Ruh\u00e9","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Radboud University Medical Centre  Nijmegen the Netherlands"},{"name":"Donders Institute for Brain, Cognition and Behavior Radboud University  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u00a0M.","family":"Bet","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacy Amsterdam University Medical Centre  Amsterdam the Netherlands"},{"name":"Amsterdam Public Health Research Institute  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline\u00a0G.","family":"Hugtenburg","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacy Amsterdam University Medical Centre  Amsterdam the Netherlands"},{"name":"Amsterdam Public Health Research Institute  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0284389"},{"key":"e_1_2_11_3_1","first-page":"1","article-title":"Antidepressant Medication Prescribing Patterns in Irish General Practice From 2016 to 2020 to Assess for Long\u2010Term Use","volume":"191","author":"McCool A.","year":"2021","journal-title":"Irish Journal of Medical Science (1971\u2010)"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480456"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.07.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2871"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(97)00018-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.02.006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.12.098"},{"key":"e_1_2_11_10_1","unstructured":"Eupen Mv \u201cLangdurig gebruik antidepressiva groeit in de eerste lijn \u201d Huisarts en Wetenschap. (2018): 2018(4)."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0910"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0843-0"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta25690"},{"key":"e_1_2_11_14_1","unstructured":"Practitioners TDCoG \u201cAnxiety: Nederlands Huisartsen Genootschap (2019) [3.1 https:\/\/richtlijnen.nhg.org\/standaarden\/angst."},{"key":"e_1_2_11_15_1","unstructured":"Practitioners TDCoG \u201cDepression \u201d (2024) https:\/\/richtlijnen.nhg.org\/standaarden\/depressie#volledige\u2010tekst\u2010medicamenteuze\u2010behandeling."},{"key":"e_1_2_11_16_1","unstructured":"NICE \u201cDepression in adults: treatment and management \u201d (2022) https:\/\/www.nice.org.uk\/guidance\/ng222\/chapter\/recommendations#choice\u2010of\u2010treatments."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/02813432.2021.2006487"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125319872344"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmm069"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp16X686641"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-046054"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-022-00960-y"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200124030-00003"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2022.10.005"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.08.011"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/20451253211067656"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30032-X"},{"key":"e_1_2_11_28_1","unstructured":"A.Horikx HJ B.F.Groeneweg L.M.Roosjen\u2010de Feiter et\u00a0al. \u201cMultidisciplinary Document \u2018Reducing SSRIs & SNRIs\u2019 \u201d (2018) https:\/\/www.knmp.nl\/sites\/default\/files\/2021\u201012\/201809%20Multidisciplinair%20document%20afbouwen%20SSRIs%20en%20SNRIs.pdf."},{"key":"e_1_2_11_29_1","unstructured":"A.Horikx KdL B.F.Groeneweg M.J.M.van denEijnden et\u00a0al. \u201cMultidisciplinary Document \u2018Discontinuation of Other Antidepressants\u2019 \u201d (2023) https:\/\/www.nhg.org\/thema\/psychische\u2010huisartsenzorg\/afbouwen\u2010overige\u2010antidepressiva\/."},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3399\/BJGP.2020.0913"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.10.107"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp24X737781"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2025.02.004"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.04.060"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-017-0605-9"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzm042"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/01612840.2015.1004605"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2021.06.006"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027837"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T06:53:11Z","timestamp":1750920791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.70051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/bcpt.70051"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.70051","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,26]]},"assertion":[{"value":"2025-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70051"}}