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Betulinic acid (BA), a pentacyclic triterpene of natural origin that was isolated from several plants, has anti\u2010inflammatory, immunomodulatory and antioxidant effects that can help with AP. With this study, we aimed to investigate the potential positive effects of BA on <jats:sc>l<\/jats:sc>\u2010arginine\u2010induced AP. A total of 24 male rats were divided into four groups (control, BA, AP and BA\u2009+\u2009AP). Animals in the BA group were given BA 50\u2009mg\/kg\/day for 7\u2009days. AP was induced by administering two doses of 250\u2010mg\/100\u2010g <jats:sc>l<\/jats:sc>\u2010arginine to animals in the AP group. The animals in the BA\u2009+\u2009AP group were administered 50\u2010mg\/kg\/day BA (gavage) for 7\u2009days and two doses of 250\u2010mg\/100\u2010g <jats:sc>l<\/jats:sc>\u2010arginine on the seventh day. BA pretreatment inhibited the increased lipase activity caused by AP and showed protective activity against oxidative damage to pancreatic tissue. It decreased the severity of inflammation by suppressing the release of pro\u2010inflammatory cytokines while increasing the level of the anti\u2010inflammatory cytokine IL\u201010. It showed a protective effect on pancreatic tissue by inhibiting tumour necrosis factor (TNF\u2010\u03b1) and Bax expression. The findings of the study show that BA exhibits multifaceted protective activity in experimental AP induced with <jats:sc>l<\/jats:sc>\u2010arginine.<\/jats:p>","DOI":"10.1111\/bcpt.70052","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T19:27:36Z","timestamp":1746732456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Potential Ability of Betulinic Acid to Prevent Experimentally Induced Acute Pancreatitis in Rats"],"prefix":"10.1111","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0819-8843","authenticated-orcid":false,"given":"Guler","family":"Yenice","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Animal Nutrition and Nutritional Disorders Ataturk University  Erzurum 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