{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:05:55Z","timestamp":1775192755146,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012155","name":"National Institute for Medical Research Development","doi-asserted-by":"publisher","award":["4021443"],"award-info":[{"award-number":["4021443"]}],"id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study assessed the effects of a hydroalcoholic extract derived from <jats:styled-content style=\"fixed-case\"><jats:italic>Melissa officinalis<\/jats:italic><\/jats:styled-content> (lemon balm) at doses of 50, 100 and 200\u2009mg\/kg in a rat model of experimental allergic asthma. We evaluated biomarkers of oxidative stress, including nitrite (NO<jats:sub>2<\/jats:sub>), malondialdehyde (MDA), thiol (SH), superoxide dismutase (SOD) and catalase (CAT), along with mediators such as interleukin\u20104 (IL\u20104), IL\u201017, interferon\u2010gamma (IFN\u2010\u03b3) and immunoglobulin E (IgE) in bronchoalveolar lavage fluid (BALF). The untreated asthmatic group showed significantly elevated levels of MDA, NO<jats:sub>2<\/jats:sub>, IL\u20104, IL\u201017 and IgE (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while levels of SH, IFN\u2010\u03b3 and the activities of SOD and CAT were markedly reduced compared with the control group. In contrast, treatment groups receiving plant extracts and dexamethasone (Dex) demonstrated a significant decrease in levels of NO<jats:sub>2<\/jats:sub>, MDA, IL\u20104, IL\u201017 and IgE. Additionally, the levels of SH, IFN\u2010\u03b3 and the activities of SOD and CAT were significantly elevated compared with the untreated asthmatic group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 to <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The therapeutic efficacy of <jats:styled-content style=\"fixed-case\"><jats:italic>Melissa officinalis<\/jats:italic><\/jats:styled-content> extract in reducing oxidative damage and inflammatory mediators in asthmatic rats was comparable to that of dexamethasone. This finding highlights the potential therapeutic benefits of the plant in alleviating asthma\u2010related symptoms.<\/jats:p>","DOI":"10.1111\/bcpt.70068","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T02:56:29Z","timestamp":1749524189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protective Effect of <scp><i>Melissa officinalis<\/i><\/scp> (Lemon Balm) Extract on Cytokine Levels and Oxidative Stress in Ovalbumin Induced Lung Toxicity in Rats"],"prefix":"10.1111","volume":"137","author":[{"given":"Vahideh","family":"Abbasnia","sequence":"first","affiliation":[{"name":"Department of Biology Payame Noor University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Foadoddini","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Research Center Birjand University of Medical Sciences  Birjand Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9854-6121","authenticated-orcid":false,"given":"Mohammad\u00a0Reza","family":"Khazdair","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Research Center Birjand University of Medical Sciences  Birjand Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00246"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138707"},{"issue":"2","key":"e_1_2_11_4_1","first-page":"225","article-title":"A Study of Home Characteristics in Children With Allergic Rhinitis and Asthma","volume":"50","author":"Salehi M.","year":"2011","journal-title":"Acta Clinica Croatica"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pathol\u2010042220\u2010015902"},{"key":"e_1_2_11_6_1","first-page":"98","article-title":"Botanical Studies of the Leaf of Melissa officinalis L., Family: Labiatae, Cultivated in Egypt","volume":"5","author":"Abdel\u2010Naime W. 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