{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:05:38Z","timestamp":1789214738610,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174061"],"award-info":[{"award-number":["82174061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374130"],"award-info":[{"award-number":["82374130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012281"],"award-info":[{"award-number":["2024A1515012281"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M750667"],"award-info":[{"award-number":["2024M750667"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Renal fibrosis is a common pathological process in chronic kidney disease (CKD), which is mainly characterized by glomerulosclerosis and tubulointerstitial fibrosis. The formation and development of renal fibrosis are stimulated by pro\u2010inflammatory as well as pro\u2010fibrosis factors released by inflammatory cells. Wuling San is an ancient Chinese classical formula for urination\u2010promoting and dampness\u2010draining, which can regulate the metabolism of water and fluid and has exerted therapeutic effects on various chronic kidney diseases by reducing oedema, inflammation, and improving glomerulosclerosis and renal interstitial fibrosis. However, further study is still needed to explore the mechanism. Based on the research analysis with the help of CiteSpace, the following three directions were the possible mechanisms in improving renal fibrosis: inhibiting the conversion of renal cells to myofibroblasts; regulating amino acid, lipid and energy metabolism and reducing extracellular matrix (ECM) deposition; and regulating the RhoA\/ROCK pathway, the downstream of G protein\u2010coupled receptor (GPCR). This review aims to summarize the mechanism of action of Wuling San in the treatment of CKD from the perspective of antifibrosis, which can help to explore the new ideas and directions of Wuling San in the treatment of renal diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcpt.70071","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T03:24:55Z","timestamp":1751253895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Review of the Delay of Chronic Kidney Disease Progression by Wuling San on Improving Renal Fibrosis"],"prefix":"10.1111","volume":"137","author":[{"given":"Zhijun","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beini","family":"Lao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou Guangdong China"},{"name":"Department of Nephrology Liwan Central Hospital of Guangzhou  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3477-3370","authenticated-orcid":false,"given":"Jiuyao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00570-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034227"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202410416"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.57.s75.9.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-024-00889-z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.12.016"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.09.002"},{"issue":"1","key":"e_1_2_9_9_1","first-page":"44","article-title":"Fuyang Method Treatment of Water\u2010Stasis Interjunction Type Renal Fibrosis","volume":"41","author":"Li J.","year":"2024","journal-title":"Tianjin Traditional 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Quantification in the Treatment of Nephrotic Syndrome","volume":"13","author":"Feng B.","year":"2021","journal-title":"TCM Clinical Research"},{"issue":"3","key":"e_1_2_9_14_1","first-page":"206","article-title":"Clinical Research Progress of Wuling Powder","volume":"48","author":"Yang Z.","year":"2021","journal-title":"Liaoning Journal of Traditional Chinese Medicine"},{"issue":"5","key":"e_1_2_9_15_1","first-page":"1","article-title":"Clinical Study on Modified Wulingsan Decoction Combined With Tacrolimus for Nephrotic Syndrome","volume":"56","author":"LI E.","year":"2024","journal-title":"New Traditional Chinese Medicine"},{"issue":"2","key":"e_1_2_9_16_1","first-page":"335","article-title":"Clinical Observation of Supplementing Wuling San to Treat Kidney Syndrome With Spleen\u2010Kidney Yang Deficiency Type","volume":"39","author":"Huang Y.","year":"2023","journal-title":"Journal of Practical Chinese 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