{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:15:10Z","timestamp":1791494110003,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Excess aldosterone production contributes to the development of hypertension and results in fibrosis with dysfunction of the heart, vasculature and kidneys. Consequently, new agents have been developed to reduce endogenous aldosterone synthesis. The primary objective of this systematic review is to describe the BP\u2010lowering effects of aldosterone synthase inhibitors (ASIs) in hypertensive patients and, secondly, to describe their potential renal protective effects and possible influence on cortisol production and plasma potassium. We searched PubMed, Embase and\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    and included randomized controlled and clinical trials according to PICO using the review tool Covidence. Thirteen studies were included and all demonstrated BP reduction through ASI treatment. Among patients with apparent resistant hypertension, the placebo\u2010corrected reductions in seated systolic BP were 11.0\u2009mmHg for baxdrostat and 9.6\u2009mmHg for lorundrostat. A significant suppression of cortisol production was found for LCI699 (osilodrostat) but not for baxdrostat, lorundrostat, BI 690517 (vicadrostat) or dexfadrostat. Studies on BI 690517 showed a reduction in urine\u2013albumin\u2013creatinine ratio, indicating renal protection. ASIs may increase potassium levels. We conclude that ASIs have promising BP\u2010lowering effects with very limited effects on cortisol production and offer reno\u2010protective effects in chronic kidney disease. Studies on hypertensive target organ damage and cardiovascular outcomes are, however, lacking.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70080","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T08:24:50Z","timestamp":1753172690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Blood Pressure\u2013Lowering Effects of Aldosterone Synthase Inhibitors\u2014A Systematic Review"],"prefix":"10.1111","volume":"137","author":[{"given":"Anders\u00a0Almskou","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Department of Biomedicine HEALTH, Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketil\u00a0Lehm","family":"Nordestgaard","sequence":"additional","affiliation":[{"name":"Department of Biomedicine HEALTH, Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-7666","authenticated-orcid":false,"given":"Ulf","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine HEALTH, Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7972-8181","authenticated-orcid":false,"given":"Niels\u00a0Henrik","family":"Buus","sequence":"additional","affiliation":[{"name":"Department of Biomedicine HEALTH, Aarhus University  Aarhus Denmark"},{"name":"Department of Renal Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)30752\u20102"},{"key":"e_1_2_11_3_1","volume-title":"Global Report on Hypertension: The Race Against a Silent Killer","year":"2023"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(15)01225\u20108"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(21)01330\u20101"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010023\u201001282\u20100"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102018\u2010313599"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2213559"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2007.09.001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.122.17964"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2018.12.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00419.2023"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaa137"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010013\u20100330\u2010y"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741\u2010016\u20109591\u20102"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.10.010"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000182661.98259.4f"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.110"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010013\u20100379\u20107"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0895\u20107061(03)00913\u20100"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010022\u201001070\u20104"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.124.23962"},{"key":"e_1_2_11_23_1","unstructured":"A Double\u2010Blind Placebo\u2010Controlled Multicenter Study to Evaluate the Efficacy and Safety of Multiple Dose Strengths of CIN\u2010107 as Compared to Placebo After 8 Weeks of Treatment in Patients With Uncontrolled Hypertension [Internet] (2021) https:\/\/clinicaltrials.gov\/study\/NCT05137002."},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ24\u20100153"},{"key":"e_1_2_11_25_1","unstructured":"S. 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