{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:22:40Z","timestamp":1789392160716,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The most important side effect of vancomycin (Vanco) is nephrotoxicity (NPT). Lycopene (Lyco) has been reported to have anti\u2010inflammatory and anti\u2010apoptotic properties in addition to its antioxidant activity. The aim is to investigate the protective efficacy of Lyco against the NPT condition that limits the use of Vanco.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A total of 48 rats were used in the study in six groups of eight rats each, namely, Corn Oil Control, Lyco 5, Lyco 10, Vanco, Vanco\u2009+\u2009Lyco 5 and Vanco\u2009+\u2009Lyco 10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Vanco (400\u2009mg\/kg, intraperitoneal) administered for 7\u2009days elevated serum BUN, creatinine, uric acid levels and renal lipid peroxidation while decreasing renal GSH and the activity of the antioxidant enzymes SOD, CAT and GPx. Vanco also increased the levels of inflammatory markers NF\u2010\u03baB, TNF\u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      , Bcl\u20103 and p38\n                      <jats:italic>\u03b1<\/jats:italic>\n                      MAPK activity. It decreased the level of AQP\u20101 and increased the level of NGAL. In addition, it activated apoptosis by decreasing Bcl\u20102 and Procas\u20103 expression levels while increasing apoptotic p53, Bax and Cyt\u2010c expression levels. Lyco treatment at both doses (5 and 10\u2009mg\/kg, orally) ameliorated NPT by reducing oxidative stress, inflammation and apoptosis, while the higher dose was more effective.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings showed that Lyco attenuated Vanco\u2010induced NPT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcpt.70084","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T08:53:58Z","timestamp":1753088038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antioxidant, Antiinflammatory and Antiapoptotic Effects of Lycopene in Rats With Vancomycin\u2010Induced Nephrotoxicity"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9723-0413","authenticated-orcid":false,"given":"H\u00fclya","family":"Demirkap\u0131\u00a0Atik","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine University of Afyon Kocatepe  Afyonkarahisar T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2411-7492","authenticated-orcid":false,"given":"Orkun","family":"Atik","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Afyon Kocatepe  Afyonkarahisar T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7541-0405","authenticated-orcid":false,"given":"Recep","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine University of Afyon 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