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Exposure to medications during pregnancy may impact offspring hearing; however, the ototoxic effects of different drugs have not been systematically investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic review and meta\u2010analysis was conducted following PRISMA guidelines and analysed 21 experimental and observational studies examining 60 drugs across various categories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Magnesium sulphate and systemic steroids, alone or in combination, showed potential protective effects towards CHL. Specific antibiotics (e.g., gentamicin and metronidazole) and non\u2010steroidal anti\u2010inflammatory drugs were associated with an increased risk of CHL. Modest evidence indicated that low\u2010dose acetylsalicylic acid increased risk, whereas higher doses did not. Other drugs, such as anti\u2010neoplastic agents and valproic acid, showed weaker associations with CHL. Most studies had methodological limitations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings highlight the urgent need for robust research to minimise preventable hearing loss in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcpt.70090","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T07:47:45Z","timestamp":1756108065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Maternal Exposure to Medications and the Risk of Congenital and Early\u2010Onset Hearing Loss in Children: A Systematic Review and a Meta\u2010Analysis"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7748-5542","authenticated-orcid":false,"given":"Asli\u00a0Sena","family":"K\u00fcc\u00fckyildiz","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of 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