{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T13:32:50Z","timestamp":1775655170077,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["SNSF"],"award-info":[{"award-number":["SNSF"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["33IC30_205800"],"award-info":[{"award-number":["33IC30_205800"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Proton Pump Inhibitors (PPIs) are widely prescribed medications globally. PPIs are often inappropriately used \u2013 for example, prescribed without a clear indication, at higher\u2010than\u2010necessary doses, or for longer durations than needed \u2013 resulting in increased risks of adverse health outcomes such as nutrient deficiencies, osteoporosis\u2010related fractures, and kidney disease. The effectiveness of current deprescribing interventions is inconsistent; this may relate to the misalignment with behavioural mechanisms, supporting the need for a mechanism\u2010driven approach that targets key behavioural determinants. We co\u2010designed a PPI deprescribing intervention with patients and health professionals for the Swiss primary care setting. This involved identifying behavioural determinants of PPI deprescribing from the literature at both the general practitioner (GP) and patient levels, mapping them to behaviour change techniques, selecting intervention elements, and developing contextualised intervention tools to effectively influence these determinants. The intervention tools were iteratively developed and assessed through qualitative methods with 16 patients and 18 health professionals. Participants considered the tools to be acceptable and practical for use in the Swiss primary care context.<\/jats:p>","DOI":"10.1111\/bcpt.70091","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T06:07:44Z","timestamp":1755670064000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development of a Deprescribing Intervention for Proton Pump Inhibitors in Primary Care: A Co\u2010Design Approach With General Practitioners and Patients"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9507-5050","authenticated-orcid":false,"given":"Kristie\u00a0Rebecca","family":"Weir","sequence":"first","affiliation":[{"name":"Institute of Primary Health Care (BIHAM) University of Bern  Bern Switzerland"},{"name":"Sydney School of Public Health Faculty of Medicine and Health, The University of Sydney  Sydney 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