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PFOA primarily targets the liver, inducing stress responses and mitochondrial\u2010mediated apoptosis, while promoting hepatoma cell proliferation through the mTOR pathway. To investigate the molecular mechanisms of PFOA\u2010induced liver cancer (LIHC), we will use a network toxicology approach that integrates multi\u2010omics data to construct a compound\u2013target\u2013disease network, focusing on potential targets like ALDH1B1, which encodes the aldehyde dehydrogenase family in the major pathway of alcohol metabolism. It is hypothesized that hepatic metabolic homeostasis is disrupted and hepatocellular carcinogenesis is ultimately promoted by PFOA through direct binding to ALDH1B1 and interference with its function. To confirm this, we will employ molecular docking and dynamics simulations to validate the binding interactions and toxicity mechanisms at the molecular level. This research aims to provide a comprehensive understanding of PFOA's hepatotoxicity and carcinogenicity while identifying potential targets for risk assessment and intervention strategies related to environmental exposure.<\/jats:p>","DOI":"10.1111\/bcpt.70101","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T10:11:52Z","timestamp":1756116712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing the Carcinogenic Potential of PFOA: A Molecular Network Approach to Liver Toxicity"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0107-6238","authenticated-orcid":false,"given":"Libi","family":"Tan","sequence":"first","affiliation":[{"name":"School of Laboratory Medicine and Biotechnology Southern Medical University  Guangzhou China"},{"name":"Department of Laboratory Medicine &amp; Central Laboratory Southern Medical University Affiliated Fengxian Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"She","sequence":"additional","affiliation":[{"name":"Xi'an Electric Power Central Hospital  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyan","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shenzhen Children's Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory for Research and Development on Clinical Molecular Diagnosis for High\u2010Incidence Diseases of Baise Affiliated Hospital of Youjiang Medical University for Nationalities  Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine and Biotechnology Southern Medical University  Guangzhou China"},{"name":"Department of Laboratory Medicine &amp; 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