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Current treatments are primarily symptomatic and fail to modify disease progression, emphasizing the urgent need for novel, mechanism\u2010based interventions. Recent advances in molecular neuroscience have identified several non\u2010classical pathogenic pathways, including neuroinflammation, mitochondrial dysfunction, impaired autophagy and proteostasis, synaptic degeneration and non\u2010coding RNA dysregulation. In this focused review, we highlight emerging molecular targets such as TREM2, NLRP3, mTOR, TFEB, PINK1 and SIRT3, which offer promising avenues for therapeutic intervention. We also address challenges in target validation and translational drug development, while proposing future research directions that may facilitate the design of more effective treatments. A deeper understanding of these molecular mechanisms is essential for developing disease\u2010modifying strategies to combat neurodegeneration.<\/jats:p>","DOI":"10.1111\/bcpt.70107","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T05:57:51Z","timestamp":1757397471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Emerging Molecular Targets in Neurodegenerative Disorders: New Avenues for Therapeutic Intervention"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9878-3431","authenticated-orcid":false,"given":"Ezgi","family":"Eroglu","sequence":"first","affiliation":[{"name":"Department of Clinical Trials Turkish Medicines and Medical Devices Agency  Ankara 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