{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:11:54Z","timestamp":1787314314301,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Bleomycin (BLM), a chemotherapeutic agent commonly used in cancer treatment, is associated with oxidative stress and testicular toxicity, leading to impaired reproductive health. Hesperidin (HES), a citrus\u2010derived flavonoid with strong antioxidant properties, has the potential to counteract these adverse effects. This study aimed to evaluate the protective effects of HES against the reproductive toxicity induced by BLM, focusing on oxidative stress, sperm characteristics and histological changes in the male reproductive system. Thirty\u2010two rats were divided into four groups: Control, BLM, HES and BLM\u2009+\u2009HES. BLM was administered intraperitoneally at 10\u2009mg\/kg twice a week, while HES was given orally at 50\u2009mg\/kg\/day for 30\u2009days. The findings revealed that BLM induced significant oxidative stress by promoting lipid peroxidation and impairing antioxidant defence mechanisms in the testis. Additionally, BLM treatment caused a marked decline in sperm motility, an increase in abnormal sperm rates and severe histopathological damage in testicular tissue. However, co\u2010administration of HES significantly mitigated these adverse effects by improving oxidative balance, restoring sperm quality and reducing histopathological injuries. In conclusion, HES demonstrated potential in alleviating BLM\u2010induced reproductive toxicity, suggesting its therapeutic role in protecting against chemotherapy\u2010induced male infertility.<\/jats:p>","DOI":"10.1111\/bcpt.70119","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T10:21:30Z","timestamp":1758622890000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hesperidin Mitigates Bleomycin\u2010Induced Testicular and Spermatological Damage in Rats"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4625-7218","authenticated-orcid":false,"given":"\u0130dris","family":"Ayhan","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Pamukkale University  Denizli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5566-8321","authenticated-orcid":false,"given":"Nese\u00a0Basak","family":"Turkmen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy Inonu University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-151X","authenticated-orcid":false,"given":"Saadet","family":"Alan","sequence":"additional","affiliation":[{"name":"Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6494-9229","authenticated-orcid":false,"given":"Muhterem","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Obstetric and Gynecology, Faculty of Veterinary Medicine Firat University  Elaz\u0131g Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-3560","authenticated-orcid":false,"given":"Osman","family":"Ciftci","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Pamukkale University  Denizli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-024-01384-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelechem.2017.09.031"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.04.012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02034932"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2019.1622741"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200501-017PP"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1993.tb01177.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2024.108721"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666050-00005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.14126"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1074"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760410001713844"},{"key":"e_1_2_7_14_1","first-page":"723","article-title":"Hesperidin Ameliorates Bleomycin\u2010Induced Experimental Pulmonary Fibrosis via Inhibition of TGF\u2010Beta1\/Smad3\/AMPK and IkappaBalpha\/NF\u2010KappaB Pathways","volume":"18","author":"Zhou Z.","year":"2019","journal-title":"EXCLI Journal"},{"key":"e_1_2_7_15_1","first-page":"2838","volume-title":"Hesperidin Shows Protective Effects on Renal Function in Ischemia\u2010Induced Acute Kidney Injury (Sprague\u2010Dawley Rats)","author":"Park W. 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