{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:34:06Z","timestamp":1788194046985,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non\u2010motor symptoms of Parkinson's disease (PD), including sleep problems and anxiety, are common and can appear before motor symptoms. Benzodiazepines and benzodiazepine\u2010related drugs (BZDR) may be used to treat these symptoms, although they are associated with an increased fall risk. It is unknown how the incidence of BZDR use changes in relation to PD diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the incidence of BZDR use in people with and without PD from 6\u2009years before to 10\u2009years after the PD diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A nationwide register\u2010based FINPARK cohort includes 18\u2009651 persons diagnosed with PD in 1996\u20132015 and their matched comparison persons (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009127\u2009806). BZDR incidence was ascertained from a national prescription register. The study adheres to RECORD\u2010PE reporting guideline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>People with PD initiated BZDR use more frequently than the comparison people (39.0% vs. 25.9%). The incidence rate was higher in the PD group throughout the study period, and the incidence began to increase 2\u2009years before and peaked at 6\u2009months before the diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The higher incidence of BZDR use in persons with PD already before the PD diagnosis may indicate non\u2010motor symptoms before the PD diagnosis. The use of fall\u2010risk increasing BZDR for people with PD is concerning, as the disease itself increases the risk of falling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcpt.70123","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:56:18Z","timestamp":1759125378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Incidence of Benzodiazepine and Benzodiazepine\u2010Related Drug Use in People With and Without Parkinson's Disease\u2014A Nationwide Cohort Study"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1409-7769","authenticated-orcid":false,"given":"Veera","family":"Lonka","sequence":"first","affiliation":[{"name":"School of Pharmacy, Faculty of Health Sciences University of Eastern Finland  Kuopio Finland"},{"name":"Kuopio Research Centre of Geriatric Care University of Eastern Finland  Kuopio 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