{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:50:22Z","timestamp":1784260222541,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014438","name":"Business Finland","doi-asserted-by":"publisher","award":["FEPOD 2117731"],"award-info":[{"award-number":["FEPOD 2117731"]}],"id":[{"id":"10.13039\/501100014438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Rapid serum paracetamol (acetaminophen) concentration measurement is essential in suspected intoxication, but centralized laboratory analyses often delay initiation of antidotal therapy. We studied the feasibility of a novel electrochemical single\u2010walled carbon nanotube\/Nafion\u2010based point\u2010of\u2010care (POC) method in detecting paracetamol in 99 suspected overdose patient serum samples. POC was compared with the standard photoelectric enzymatic method (PEM) and ultra\u2010high performance liquid chromatography\u2013photodiode array and corona\u2010charged aerosol detector (UHPLC\u2010DAD\u2010CAD). We also analysed for 900 concomitant pharmaceuticals, drugs and chemicals in 197 samples with time\u2010of\u2010flight mass spectrometry to assess interference with paracetamol concentration measurements. Paracetamol concentrations measured with UHPLC\u2010DAD\u2010CAD ranged between 0 and 2100\u2009\u03bcmol\/L, with 19% above the therapeutic level (\u2265\u2009200\u2009\u03bcmol\/L). Comparing POC with UHPLC\u2010DAD\u2010CAD, the false positives and negatives were 10% and 15%, respectively, at concentrations \u2265\u200930\u2009\u03bcmol\/L. All POC method false negatives occurred at concentrations &lt;\u200945\u2009\u03bcmol\/L. PEM showed 8% false positives and negatives compared with UHPLC\u2010DAD\u2010CAD. Other substances detected included caffeine (78%), antidepressants (41%), benzodiazepines (34%) and antipsychotics (28%). They did not interfere with POC concentration measurement. The novel POC method is promising for measuring serum paracetamol at relevant concentrations.<\/jats:p>","DOI":"10.1111\/bcpt.70127","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T07:42:49Z","timestamp":1759822969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electrochemical Point\u2010of\u2010Care Test for Assessing Serum Paracetamol Concentration: Comparison With Traditional Methods and Detection of Concomitant Drugs"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8779-1914","authenticated-orcid":false,"given":"Johanna\u00a0K.","family":"Kujala","sequence":"first","affiliation":[{"name":"Individualized Drug Therapy Research Program, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Department of Anaesthesiology, Intensive Care and Pain Medicine Helsinki University and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-1780","authenticated-orcid":false,"given":"Terhi\u00a0J.","family":"Lohela","sequence":"additional","affiliation":[{"name":"Individualized Drug Therapy Research Program, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Department of Anaesthesiology, Intensive Care and Pain Medicine Helsinki University and Helsinki University Hospital  Helsinki Finland"},{"name":"Department of Clinical Pharmacology, Faculty of Medicine University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7937-9011","authenticated-orcid":false,"given":"Niklas","family":"Wester","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Materials Science, School of Chemical Engineering Aalto University  Helsinki Finland"},{"name":"Department of Electrical 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