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Based on receptor selectivity, the neurotoxins can be broadly classified as \u03b1\u2010neurotoxins, k\u2010neurotoxins and muscarinic toxins. The three\u2010finger neurotoxins are nonenzymatic and possess a conserved structural feature consisting of loops of \u03b2\u2010stranded loops protruding from a globular hydrophobic core held together by conserved disulfide bonds. The snake venom neurotoxins were first reported approximately 60\u2009years ago, and their discovery has since expanded our knowledge of membrane receptors and ion channels. The interactions of these neurotoxins with receptors are of special interest for their potential use in the treatment of neurodegenerative diseases, pain and cancer. This review focuses on the snake venom neurotoxins and neurotoxin\u2010like proteins and their subtypes, structural aspects of their mechanisms of action and specificity for receptors or ligand\u2010binding interfaces. Further, a detailed discussion is added on the pharmacological potential of these toxins for use as probes or potential targets in drug discovery.<\/jats:p>","DOI":"10.1111\/bcpt.70144","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T13:24:40Z","timestamp":1763040280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Snake Venom Three\u2010Finger Neurotoxins and Neurotoxin\u2010Like Proteins: Insights Into Their Structural and Functional Aspects Along With Their Pharmacological Potential"],"prefix":"10.1111","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6108-9040","authenticated-orcid":false,"given":"Manisha","family":"Choudhury","sequence":"first","affiliation":[{"name":"Department of Zoology Gauhati University  Guwahati India"},{"name":"Department of Biotechnology The Assam Royal Global University  Guwahati India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6942-4213","authenticated-orcid":false,"given":"Manas","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Zoology Gauhati University  Guwahati India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2012.10.020"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.01.009"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.3228405"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00239\u2010003\u20102461\u20102"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2010.07.010"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u20104658.2011.08115.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2012.09.008"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2018.12.004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1197"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.09.029"},{"key":"e_1_2_5_12_1","first-page":"693","article-title":"Evolution of Three\u2010Finger Toxins\u2014A Versatile Mini Protein Scaffold","volume":"58","author":"Kini R. 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