{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:18:52Z","timestamp":1785284332300,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Epigallocatechin\u20103\u2010gallate (EGCG) is a polyphenolic compound with strong antioxidant properties and is abundantly found in green tea. We investigated how EGCG affects the liver injury of high\u2010dose paracetamol in this study. In our study, 56 rats were divided into seven groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098): healthy control, EGCG (100\u2009mg\/kg), paracetamol (2\u2009g\/kg), paracetamol\u2009+\u2009EGCG 25 (2\u2009g\/kg\u2009+\u200925\u2009mg\/kg), paracetamol\u2009+\u2009EGCG 50 (2\u2009g\/kg\u2009+\u200950\u2009mg\/kg), paracetamol\u2009+\u2009EGCG 100 (2\u2009g\/kg\u2009+\u2009100\u2009mg\/kg) and paracetamol\u2009+\u2009N\u2010acetyl cysteine (NAC, 2\u2009g\/kg\u2009+\u2009140\u2009mg\/kg). Our findings suggest that high\u2010dose paracetamol induces liver injury through endoplasmic reticulum (ER) stress and that EGCG alleviates liver injury by attenuating ER stress\u2010induced inflammasome signalling.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70155","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:32:29Z","timestamp":1764840749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Epigallocatechin\u20103\u2010Gallate Provides Hepatoprotection Through Endoplasmic Reticulum Stress\/TXNIP\/NLRP3 Axis in Paracetamol\u2010Induced Acute Liver Injury"],"prefix":"10.1111","volume":"138","author":[{"given":"Nagihan","family":"Demirtas","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Busra Sahin","family":"Mazlumoglu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevra Aydemir","family":"Celep","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Veterinary Medicine Atat\u00fcrk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0836-7205","authenticated-orcid":false,"given":"Elif","family":"Cadirci","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekai","family":"Halici","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Ataturk University  Erzurum 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