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Using pharmacokinetic models, we simulated delayed and missed doses in virtual kidney and liver transplant recipients. Our simulations showed that a missed dose significantly lowers exposure, with recovery taking 2\u20134\u2009days. For delays shorter than 12\u2009h, the full dose should be taken immediately; for delays between 12 and 24\u2009h, half the dose should be administered; for a missed dose, 150% should be given at the next intake. These strategies may help maintain therapeutic exposure and preserve transplant outcomes.<\/jats:p>","DOI":"10.1111\/bcpt.70157","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:10:17Z","timestamp":1764839417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Managing Delayed or Missed Doses of Prolonged\u2010Release Tacrolimus in Transplant Recipients: Implications for Drug Exposure and Recovery Strategies"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3161-4493","authenticated-orcid":false,"given":"S.","family":"Arraki\u00a0Zava","sequence":"first","affiliation":[{"name":"Pharmacology, Toxicology and Pharmacovigilance Department Limoges University Hospital  Limoges 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