{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:15:04Z","timestamp":1777979704601,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Triclosan (TCS) is a widely used antimicrobial agent raising concern about its potential toxicity and adverse effects on fertility. This study investigated the protective efficacy of clomiphene citrate, conventional selenium, nanoselenium and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Tribulus terrestris<\/jats:italic>\n                    <\/jats:styled-content>\n                    extract (TTE) against TCS\u2010induced toxicity in male rats. Six experimental groups were established: control, TCS\u2010exposed and TCS co\u2010treated with each therapeutic agent. Semen quality; testicular and hepatic biochemical, oxidative and mitochondrial markers; hormone profiles; neurotransmitters; and histopathology were assessed. Specific reproductive (SOX9, inhibin B) and hepatic (Nrf2, NF\u2010\u03baB) markers were quantified to evaluate spermatogenesis, oxidative stress and inflammatory responses. In silico analyses, including molecular docking and molecular dynamics simulations, examined the interactions of TCS with CYP17A1 and GPX4 to elucidate potential mechanisms of enzyme inhibition. The results demonstrated that TCS exposure impaired reproductive and hepatic function, disrupted hormonal balance, induced oxidative stress and tissue damage. Treatments with selenium (conventional and nanoforms) and\n                    <jats:italic>TTE<\/jats:italic>\n                    significantly mitigated these alterations, restoring biochemical and hormonal parameters and improving tissue architecture. Among these, nanoselenium and TTE showed the most pronounced protective effects, emphasizing their comparative efficacy in counteracting TCS\u2010induced toxicity. The findings highlight the potential of nanoselenium and TTE as promising protective agents against TCS\u2010related reproductive and hepatic damage.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70161","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T05:00:36Z","timestamp":1765515636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In Vivo and In Silico Dissection of Triclosan\u2010Induced Reproductive Toxicity: Protective Potentials of Nanoselenium and Phytotherapy"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3012-9118","authenticated-orcid":false,"given":"Marwan\u00a0A.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Biology, College of Science Majmaah University  Al Majmaah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9689-9218","authenticated-orcid":false,"given":"Barga","family":"Aboukhezam","sequence":"additional","affiliation":[{"name":"Physiology, Zoology Department, Faculty of Science University of Tripoli  Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6915-0421","authenticated-orcid":false,"given":"Fayzah\u00a0A.","family":"Aboubakr","sequence":"additional","affiliation":[{"name":"Physiology, Zoology Department, Faculty of Science Sebha University  Sebha Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-0183","authenticated-orcid":false,"given":"Einas\u00a0M.","family":"Yousef","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Genetics, College of Medicine Alfaisal University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4335-7443","authenticated-orcid":false,"given":"Hajir\u00a0A.\u00a0Al","family":"Saihati","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences University of Hafr Albatin  Hafr Albatin Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walaa\u00a0S.\u00a0Saif\u00a0El","family":"Nasr","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Egyptian Drug Authority  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azizeh","family":"Shadidizaji","sequence":"additional","affiliation":[{"name":"Vaccine Development Application and Research Center Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3057-3016","authenticated-orcid":false,"given":"Ayman\u00a0Mohamed","family":"Algohary","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Majah University  Al Majmaah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1020-5777","authenticated-orcid":false,"given":"Omar\u00a0A.","family":"Ahmed\u00a0Farid","sequence":"additional","affiliation":[{"name":"Department of Physiology Egyptian Drug Authority  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0516-4023","authenticated-orcid":false,"given":"Mohamad","family":"Warda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Cairo University  Giza Egypt"},{"name":"Department of Physiology, Faculty of Veterinary Medicine Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.113617"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.26444\/jpccr\/142065"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2024.1469340"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010024\u201001662\u20100"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.18502\/jfrh.v16i1.8592"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312735"},{"key":"e_1_2_15_8_1","unstructured":"X. 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