{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:30:30Z","timestamp":1790814630824,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Central nervous system tuberculosis (CNS\u2010TB) represents a critical form of extrapulmonary tuberculosis, characterized by high mortality and morbidity. The infection of microglia by\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    <\/jats:styled-content>\n                    (\n                    <jats:italic>Mtb<\/jats:italic>\n                    ) is a crucial factor in the progression of CNS\u2010TB. Ferroptosis plays a significant role in various neurological disorders. However, it remains unclear whether\n                    <jats:italic>Mtb<\/jats:italic>\n                    can induce ferroptosis in microglia and what mechanisms underlie this process. This study demonstrated that\n                    <jats:italic>Mtb<\/jats:italic>\n                    H37Rv infection can induce ferroptosis in microglia, which is characterized by the accumulation of ferrous ions, increased levels of lipid ROS, depletion of glutathione, enhanced lipid peroxidation and reduced expression of Slc7a11 and Gpx4. Additionally,\n                    <jats:italic>Mtb<\/jats:italic>\n                    infection upregulated Sp1 expression, and Sp1 knockdown led to a suppression of ferroptosis induced by\n                    <jats:italic>Mtb<\/jats:italic>\n                    . Mechanistically, we found that Sp1 enhanced the transcription of Mettl14. Subsequently, the N6\u2010methyladenosine modification mediated by Mettl14 stabilized the mRNA of Acsl4, ultimately inducing ferroptosis. Mettl14 also was found to enhance the stability of Sp1 mRNA, establishing a positive regulatory feedback loop. Moreover, knockdown of Acsl4 attenuated Sp1\u2010 or Mettl14\u2010mediated ferroptosis in\n                    <jats:italic>Mtb<\/jats:italic>\n                    \u2010infected microglia. Overall, our findings establish a connection between\n                    <jats:italic>Mtb<\/jats:italic>\n                    infection and ferroptosis and delineate a novel mechanism through which H37Rv induces ferroptosis in microglia via the Sp1\u2010Mettl14\u2010Acsl4 axis, offering new insights into the pathogenesis of CNS\u2010TB.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70183","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:26:06Z","timestamp":1768623966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sp1\u2010Mettl14 Feedback Loop Promotes Ferroptosis in\n                    <scp>\n                      <i>Mycobacterium tuberculosis<\/i>\n                    <\/scp>\n                    \u2013Infected Microglia by Activating Acsl4"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5531-3973","authenticated-orcid":false,"given":"Junhao","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Neurology Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quansheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aili","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of North Sichuan Medical College  Nanchong 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