{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:02:34Z","timestamp":1773028954416,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2022\u201020\u20104"],"award-info":[{"award-number":["320.6750.2022\u201020\u20104"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>While current studies have focused on the incidence of moxifloxacin\u2010associated liver injury, risk factors and clinical characteristics for moxifloxacin\u2010induced liver injury in hospitalized patients remain unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed antibiotic\u2010induced liver injury using the US Food and Drug Administration Adverse Event Reporting System (FAERS) database. A retrospective observational study was further conducted on 1265 hospitalized patients treated with moxifloxacin for infections. Independent risk factors for moxifloxacin\u2010induced DILI were identified via multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FAERS data indicated that moxifloxacin\u2010induced liver injury exacerbates clinical outcomes, prolongs hospitalization, and may be life\u2010threatening. Infections were the primary indication for fluoroquinolone use, with gender\u2010specific differences observed in liver injury profiles across quinolones. Retrospective analyses revealed gender as an independent protective factor (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Risk factors included hypoalbuminemia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), hepatic comorbidities (fatty liver,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013; pre\u2010existing liver injury,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.013), elevated baseline alkaline phosphatase (ALP,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and concomitant use of traditional Chinese medicine or respiratory drugs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite widespread clinical use, moxifloxacin's safety profile requires systematic evaluation. Clinicians should monitor liver function and integrate risk stratification, including albumin levels, gender and concomitant medications into prescribing practices. Elucidating DILI mechanisms and high\u2010risk populations may optimize therapeutic decision\u2010making and patient safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcpt.70187","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T13:19:45Z","timestamp":1767187185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug\u2010Induced Liver Injury Associated With Moxifloxacin: A Pharmacovigilance Analysis of the FDA Adverse Event Reporting System and a Real\u2010World Retrospective Study"],"prefix":"10.1111","volume":"138","author":[{"given":"Yanqing","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pharmacy Lequn Branch, the First Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunzi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Lequn Branch, the First Hospital of Jilin University  Changchun China"},{"name":"Jilin Medical Association Secretariat  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy the First Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5072-841X","authenticated-orcid":false,"given":"Huan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy the First Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2015.10.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32283"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2017.08.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079907X188099"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1367"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.111823"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.994821"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.56.8369"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.553"},{"key":"e_1_2_11_11_1","unstructured":"European Medicines Agency \u201cAssessment Report. Referral Under Article 31 of Directive 2001\/83\/EC Resulting From Pharmacovigilance Data: Quinolone and Fluoroquinolone Medicinal Products for Systemic and Inhalation Use (EMA\/818158\/2018) \u201d2018"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9302733"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-022-00635-7"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26246"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.891336"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2024.01.001"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15050645"},{"issue":"6","key":"e_1_2_11_18_1","article-title":"BCPT 2026 Policy for Experimental and Clinical Studies","volume":"137","author":"Tveden\u2010Nyborg P.","year":"2025","journal-title":"British Journal of Clinical Pharmacology"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1378090"},{"key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2147\/DMSO.S348025","article-title":"Difference in Gastrointestinal Risk Associated With Use of GLP\u20101 Receptor Agonists: A Real\u2010World Pharmacovigilance Study","volume":"15","author":"Yu Z.","year":"2022","journal-title":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2021-101886"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.58"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.08.008"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010014"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14847"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.03.006"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.006"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.02.002"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-017-0547-9"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.35.967"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.04.024"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc1022"},{"issue":"8","key":"e_1_2_11_33_1","first-page":"1009","article-title":"A Systematic Review of the Definitions, Determinants, and Clinical Outcomes of Antimicrobial De\u2010Escalation in the Intensive Care Unit","volume":"62","author":"Alexis T.","year":"2015","journal-title":"Clinical Infectious Diseases"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-69279-6"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1126765"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2024.135896"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2020.02.003"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2017.1317349"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.03.021"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2014-0214-RA"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.02.019"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9085-y"},{"issue":"9","key":"e_1_2_11_43_1","first-page":"688","article-title":"Prevalence and Risk Factors of Anti\u2010Tuberculosis Drug\u2010Induced Hepatitis in Malaysia","volume":"49","author":"Marzuki O. A.","year":"2008","journal-title":"Singapore Medical Journal"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12071183"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp130165"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S195802"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/1120009X.2023.2203607"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcpt.70187","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:59:41Z","timestamp":1773025181000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.70187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/bcpt.70187"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.70187","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,31]]},"assertion":[{"value":"2025-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70187"}}