{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:00:15Z","timestamp":1773028815712,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Due to recently emerging concerns about the nonmedical use of tramadol in Denmark, we hypothesized increasing tramadol detections in medico\u2010legal autopsy cases, with more nonprescribed use and fatal poisonings over time, particularly among young individuals. In 2013\u20132024, we detected tramadol in 205 decedents. Fourteen (7%) had age \u2264\u200925\u2009years. Apparently, 82 (40%) had no prescription. Tramadol poisoning caused death in 60 (29%), including 4 (2%) with age\u2009\u2264\u200925. There were 12 accidental poisonings with tramadol alone (age (median [interquartile range]): 52 [46\u201355] years, tramadol concentration: 3.5 [1.8\u20135.2] mg\/kg, number of detected drugs: 3 [2.5\u20139]), and 25 accidental poisonings with tramadol and other drugs (age: 43 [32\u201347] years, tramadol concentration: 0.78 [0.13\u20131.3] mg\/kg, number of detected drugs: 7 [5\u201310]). Tramadol\u2010positive decedents, decedents without prescription and tramadol poisonings peaked in 2017, with no subsequent increase. Conclusively, data from our area showed no consistent rise in tramadol\u2010positive decedents, nonprescribed use or related poisonings. Accidental tramadol fatalities mostly occurred in middle\u2010aged people and\/or were associated with polydrug use. Young decedents were infrequent. However, serious consequences of nonmedical tramadol use other than death, which are not captured in medico\u2010legal autopsy data, can occur. Therefore, preventive measures are still crucial to curb nonmedical tramadol use.<\/jats:p>","DOI":"10.1111\/bcpt.70191","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:37:19Z","timestamp":1768905439000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tramadol\u2010Related Deaths Over a 10\u2010Year Period\u2014An Autopsy Study From Western Denmark"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0165-6994","authenticated-orcid":false,"given":"Terese\u00a0Matthesen","family":"Kamronn","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Forensic Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asser\u00a0Hedegaard","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine\u00a0Solveig","family":"Aftret","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen\u00a0Bo","family":"Hasselstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte\u00a0Uggerh\u00f8j","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Forensic Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2801-5"},{"key":"e_1_2_9_3_1","volume-title":"Medical Genetics Summaries","author":"Dean L.","year":"2012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000722"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199700532-00006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-020-01012-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.108367"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.09.018"},{"key":"e_1_2_9_9_1","unstructured":"United Nations Office on Drugs and Crime \u201cWorld Drug Report \u201d (2024) https:\/\/wwwunodcorg\/documents\/data\u2010and\u2010analysis\/WDR_2024\/WDR24_Key_findings_and_conclusionspdf."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15323"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40801-019-00163-w"},{"key":"e_1_2_9_12_1","unstructured":"Danish Medicines Agency \u201cNy Rapport om Bivirkningsindberetninger om den Smertestillende Medicin Tramadol (New Report on Adverse Event Reports Concerning the Pain Medication Tramadol) \u201d (2018) https:\/\/laegemiddelstyrelsen.dk\/da\/nyheder\/2018\/ny\u2010rapport\u2010om\u2010bivirkningsindberetninger\u2010om\u2010den\u2010smertestillende\u2010medicin\u2010tramadol."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.16360"},{"key":"e_1_2_9_14_1","unstructured":"Retsinformation \u201cBekendtg\u00f8relse om \u00c6ndring af Bekendtg\u00f8relse om Euforiserende Stoffer \u201d 2022. (Executive Order Amending the Executive Order on Euphoric Substances) (2022) https:\/\/www.retsinformation.dk\/eli\/lta\/2022\/424."},{"key":"e_1_2_9_15_1","unstructured":"M.Nygaard\u2010Christensen B.Thylstrup E.Houborg et\u00a0al. \u201cBrug af Receptpligtige Opioider Blandt Unge i Danmark Resultater fra Kvalitative og Kvantitative Studier \u201d Faglig Rapport fra Center for Rusmiddelforskning Aarhus Universitet (Use of Prescription Opioids Among Young People in Denmark. Results From Qualitative and Quantitative Studies. Scientific Report From the Centre for Alcohol and Drug Research Aarhus University 2024) (2024) https:\/\/psy.au.dk\/fileadmin\/site_files\/filer_rusmiddelforskning\/dokumenter\/rapporter\/2024\/Brug_af_receptpligtige_opioider_blandt_unge_i_Danmark_Rapport_fra_Center_for_Rusmiddelforskning_Aarhus_Universitet._Juli_2024.pdf."},{"key":"e_1_2_9_16_1","unstructured":"Danish Health Authority \u201cUnge og Opioider \u201d En SSP\u2010Unders\u00f8gelse i de Danske Kommuner (Young People and Opioids. An SSP Study in Danish Municipalities) (2023) https:\/\/www.ism.dk\/Media\/638218846540121020\/SSP\u2010Samraadet\u2010Kortlaegning\u2010Unge\u2010og\u2010opioider.pdf."},{"key":"e_1_2_9_17_1","unstructured":"Statistics Denmark.Report https:\/\/www.dst.dk\/da\/Statistik\/emner\/befolkning\u2010og\u2010valg\/doedsfald\u2010og\u2010middellevetid\/doedsfald."},{"issue":"1","key":"e_1_2_9_18_1","article-title":"Fatal Poisoning Among Drug Users in Denmark in 2017","volume":"68","author":"Simonsen K. W.","year":"2020","journal-title":"Danish Medical Journal"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","unstructured":"The Danish Ministry of Health \u201cSundhedsloven (Act of Health) \u201d LBK nr 903 af 26\/08\/2019 (2019) https:\/\/www.retsinformation.dk\/eli\/lta\/2019\/903.","DOI":"10.1093\/jamia\/ocz080"},{"key":"e_1_2_9_20_1","unstructured":"K.ThestrupandM. L.Andrease \u201cCirkul\u00e6reskrivelse om Foretagelse af Lovm\u00e6ssig Obduktion i Tilf\u00e6lde af D\u00f8dsfald Der m\u00e5 Antages at St\u00e5 i Forbindelse Med Misbrug af Euforiserende Stoffer 1970 \u201d (Circular Letter on the Performance of Statutory Autopsies in Cases of Death Presumed to be Related to the Abuse of Euphoric Substances) https:\/\/www.retsinformation.dk\/eli\/mt\/1970\/254."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2016.07.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.2655"},{"key":"e_1_2_9_23_1","volume-title":"Baselt","author":"Baselt R.","year":"2020"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02915-5"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-020-03016-6"},{"issue":"6","key":"e_1_2_9_28_1","article-title":"Access to Psychotropic Medication via Prescription Is Associated With Choice of Psychotropic Medication as Suicide Method: A Retrospective Study of 27,876 Suicide Attempts","volume":"79","author":"Brown T. L.","year":"2018","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/bcp.70060"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsir.2025.100408"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.61409\/A03250147"},{"key":"e_1_2_9_32_1","article-title":"Prevalence and Characteristics of Tramadol\u2010Induced Seizures in Young Adult Emergency Admissions","volume":"72","author":"Nielsen A. V. A.","year":"2025","journal-title":"Danish Medical Bulletin"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.70044"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1508490"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcpt.70191","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:59:36Z","timestamp":1773025176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.70191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/bcpt.70191"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.70191","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]},"assertion":[{"value":"2025-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70191"}}