{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:36:54Z","timestamp":1781005014073,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009697","name":"Hashemite University","doi-asserted-by":"publisher","award":["54\/2020"],"award-info":[{"award-number":["54\/2020"]}],"id":[{"id":"10.13039\/501100009697","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2026R73"],"award-info":[{"award-number":["PNURSP2026R73"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Chlorpyrifos (CPF) triggers cardiotoxicity associated with oxidative stress, inflammation and apoptosis. This study investigated whether isorhamnetin, a chemically defined flavonol (3\u2032\u2010\n                      <jats:italic>O<\/jats:italic>\n                      \u2010methylquercetin, C\n                      <jats:sub>16<\/jats:sub>\n                      H\n                      <jats:sub>12<\/jats:sub>\n                      O\n                      <jats:sub>7<\/jats:sub>\n                      , purity\u2009\u2265\u200998%), could mitigate CPF\u2010induced myocardial injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male Wistar rats were randomly divided into control, isorhamnetin, CPF and CPF\u2009+\u2009isorhamnetin groups. Cardiac biomarkers, oxidative\/antioxidant status, and inflammatory and apoptotic mediators in conjunction with histopathology and Nrf2\/HO\u20101 signalization were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CPF elevated serum cTnI, CK\u2010MB and LDH (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), attaining lower levels after isorhamnetin cotreatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). TBARS and NO were elevated (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas GSH, SOD, catalase and GPx decreased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) after CPF exposure; these indices were reverted with isorhamnetin. CPF increased the expression levels of NF\u2010\u03baB p65, TNF\u2010\u03b1, IL\u20106 and IL\u20101\u03b2 proteins and decreased that of IL\u201010 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas isorhamnetin offset these effects (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Apoptosis was apparent with high Bax and caspase\u20103 and low Bcl\u20102 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); all were ameliorated by isorhamnetin. Histopathological alterations caused by CPF were ameliorated. CPF downregulated the expression and activity of Nrf2\/HO\u20101 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), but this pathway was significantly induced by isorhamnetin (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Isorhamnetin alleviates CPF\u2010induced cardiotoxicity by restoring redox balance and modulating inflammatory and apoptotic pathways through Nrf2\/HO\u20101 signalling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcpt.70197","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:34:43Z","timestamp":1773012883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Isorhamnetin Protects Against Organophosphate\u2010Induced Cardiac Damage in Wistar Rats Through Redox Balance and Nrf2\/HO\u20101 Signalling"],"prefix":"10.1111","volume":"138","author":[{"given":"Yousra","family":"Bseiso","sequence":"first","affiliation":[{"name":"Department of Biology and Biotechnology, Faculty of Science The Hashemite University  Zarqa Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badriyah\u00a0S.","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy Princess Nourah Bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-6338","authenticated-orcid":false,"given":"Alaa\u00a0A.\u00a0A.","family":"Aljabali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy Yarmouk University  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8801-2652","authenticated-orcid":false,"given":"Omar","family":"Gammoh","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy Yarmouk University  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3766-5781","authenticated-orcid":false,"given":"Muna","family":"Oqal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences The Hashemite University  Zarqa Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad\u00a0E.","family":"Rabeh","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy Jerash University  Jerash Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad\u00a0M.","family":"Rabi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy Jerash University  Jerash Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esam","family":"Qnais","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology, Faculty of Science The Hashemite University  Zarqa Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3721-8225","authenticated-orcid":false,"given":"Abdelrahim","family":"Alqudah","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences The Hashemite University  Zarqa Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Insecticides: Action and Metabolism","author":"O'Brien R. 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