{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:16:24Z","timestamp":1773029784335,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005703","name":"Akdeniz \u00dcniversitesi","doi-asserted-by":"publisher","award":["2012.01.0115.005"],"award-info":[{"award-number":["2012.01.0115.005"]}],"id":[{"id":"10.13039\/501100005703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ochratoxin A (OTA) is a nephrotoxic mycotoxin associated with renal tumour development, particularly in male rats. However, the influence of sex hormones on OTA toxicity in females remains unclear. This study investigated the roles of oestrogen and testosterone in modulating OTA nephrotoxicity in female Wistar rats. Four\u2010month\u2010old females (~220\u2009g) were divided into four groups: intact (F\u2010OTA), ovariectomized (F\u2010OVA\u2010OTA), testosterone\u2010supplemented (F\u2010OTA\u2010Test) and antitestosterone\u2010treated (F\u2010OTA\u2010Antitest). Animals received OTA (40\u2009\u03bcg\/rat\/day, feed) for 9 or 24\u2009weeks. Hormonal manipulations involved subcutaneous testosterone (625\u2009\u03bcg\/rat) or intramuscular antitestosterone (6.25\u2009\u03bcg\/rat) for 9\u2009weeks. Plasma OTA concentrations were higher in intact (12.43\u2009\u03bcg\/mL) and antitestosterone (13.46\u2009\u03bcg\/mL) rats than in ovariectomized (9.67\u2009\u03bcg\/mL) or testosterone\u2010supplemented (9.76\u2009\u03bcg\/mL) groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Renal histopathology scores (0\u20133) showed most severe lesions in testosterone\u2010treated rats (2.71\u2009\u00b1\u20090.75), followed by ovariectomized (2.14\u2009\u00b1\u20090.69), intact (1.60\u2009\u00b1\u20090.54) and antitestosterone (1.00\u2009\u00b1\u20090.00) animals (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). These findings demonstrate that oestrogen enhances OTA accumulation, whereas testosterone exacerbates renal damage. Conversely, blocking testosterone confers histological protection, suggesting a protective effect of oestrogen. Collectively, the results reveal a hormonal antagonism, with oestrogen and testosterone exerting opposing influences on OTA toxicodynamics, carrying important implications for sex\u2010specific mycotoxin risk assessment.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70201","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T11:45:49Z","timestamp":1770119149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex Hormones Differentially Modulate Ochratoxin A\u2013Induced Nephrotoxicity in Female Rats"],"prefix":"10.1111","volume":"138","author":[{"given":"Firdes\u00a0Mor","family":"Savas","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology Burdur Mehmet Akif Ersoy University  Burdur T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4356-3343","authenticated-orcid":false,"given":"Mehmet\u00a0Akif","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Biology Akdeniz University  Antalya T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-1082","authenticated-orcid":false,"given":"Ozlem","family":"Ozmen","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Pathology Burdur Mehmet Akif Ersoy University  Burdur T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.12681\/jhvms.26606"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2011.05.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00439339.2022.2102170"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2040461"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2014.03.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/75.4.733"},{"key":"e_1_2_10_8_1","volume-title":"NTP Technical Report on the Toxicology and Carcinogenesis Studies of Ochratoxin A (CAS No. 30\u201047\u20109) in F344\/N Rats (Gavage Studies). 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