{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:15:16Z","timestamp":1773029716511,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["311940\/2022\u20106"],"award-info":[{"award-number":["311940\/2022\u20106"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["APQ\u20101037\u20102.10\/24"],"award-info":[{"award-number":["APQ\u20101037\u20102.10\/24"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Asthma is a serious global health issue that affects millions of people worldwide. It is a heterogeneous disease characterized by inflammation, bronchial hyperresponsiveness and airway remodelling. Compounds from the coumarin class have been extensively documented in the literature as promising agents for asthma treatment. This review highlights the potential of coumarins and their effects in animal models of asthma. Articles from the past 10 years (2014\u20132024) were selected according to the guidelines of the PRISMA from the PubMed, Virtual Health Library (BVS) and ScienceDirect databases. The search strategy utilized descriptors from the Medical Subject Headings (MeSH) and Descriptors in Health Sciences (DeCS) databases. Were selected 18 articles after applying the inclusion criteria: full\u2010text articles published in English and Portuguese, freely accessible and investigating coumarins and their derivatives with antiasthmatic activity. The coumarins most explored by the authors were imperatorin and osthole, and the results showed that these coumarins relax airway smooth muscle, reduce inflammation and the release of Th2 cytokines IL\u20104, IL\u20105 and IL\u201013 and increase protection against inflammation through pro\u2010inflammatory cells, Th1, macrophages and dendritic cells. Thus, it is concluded that coumarins and their effects, particularly imperatorin and osthole, present a promising potential in asthma management and could serve as important molecular scaffolds for future investigations.<\/jats:p>","DOI":"10.1111\/bcpt.70210","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:02:07Z","timestamp":1771052527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coumarins and Their Derivatives in Animal Models of Asthma: A Systematic Review"],"prefix":"10.1111","volume":"138","author":[{"given":"I\u00eada\u00a0Maria","family":"dos Santos","sequence":"first","affiliation":[{"name":"Postgraduate Program in Biotechnology State University of Feira de Santana  Feira de Santana Bahia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o\u00a0L\u00e1zaro","family":"de Oliveira\u00a0Rocha","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pharmacology Federal University of the S\u00e3o Francisco Valley  Petrolina Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1000-0114","authenticated-orcid":false,"given":"Edilson\u00a0Beserra","family":"de Alencar\u00a0Filho","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biosciences Federal University of the S\u00e3o Francisco Valley  Petrolina Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabr\u00edcio\u00a0Souza","family":"Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biotechnology State University of Feira de Santana  Feira de Santana Bahia Brazil"},{"name":"Laboratory of Experimental Pharmacology Federal University of the S\u00e3o Francisco Valley  Petrolina Pernambuco Brazil"},{"name":"Postgraduate Program in Biosciences Federal University of the S\u00e3o Francisco Valley  Petrolina Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4682"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28482"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1613125"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12557"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2020.07.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202003\u20100729le"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA05643H"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155972"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2025.114480"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201701073"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.07.033"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071499"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.05.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.04.030"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27207028"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114401"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2023.69.15.1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00703"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.71"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7099097"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2017.01.011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4934592"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.572463"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aax0273"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111798"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2014.947035"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.03.029"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24081620"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116664"}],"container-title":["Basic &amp; 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