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Quercetin may facilitate the reduction of nitrite to NO. However, the combined effects of nitrite and Quercetin on gastric NO formation and blood pressure have not been explored. We investigated whether oral treatment with Quercetin enhances the gastric conversion of nitrite to NO (in vitro and in\u00a0vivo) and exerts antioxidant and antihypertensive effects. Spontaneously hypertensive rats (SHR) were divided into six groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096\/group): three groups treated with Quercetin 10\u2009mg\/kg followed 15\u2009min later by water, nitrite 1\u2009mg\/kg (nonantihypertensive) or 15\u2009mg\/kg (antihypertensive) by gavage, and three similar control groups treated with vehicle, followed by the same nitrite treatments. Blood pressure, gastric NO, plasma nitrite, nitrate, nitrosylated species (RxNO) and aortic S\u2010nitrosylated proteins were measured. Oxidative stress was also assessed. Quercetin treatment converted a nonantihypertensive dose of nitrite into an effective antihypertensive intervention in association with increased in\u00a0vitro and in\u00a0vivo gastric NO formation. However, Quercetin did not enhance nitrite\u2010induced increases in systemic or vascular nitrite, nitrate, RxNO concentrations nor vascular protein nitrosation. Our results show that Quercetin is a potent enhancer of gastric NO formation from nitrite and amplifies its antihypertensive effects. This combination of drugs may represent a safe and effective therapeutic strategy.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70211","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T01:47:20Z","timestamp":1770860840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quercetin Enhances Gastric Nitric Oxide Formation and Potentiates the Antihypertensive Effects of Oral Nitrite Administration"],"prefix":"10.1111","volume":"138","author":[{"given":"Mila","family":"Silva\u2010Cunha","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Ribeirao Preto Medical School University of Sao Paulo  Ribeirao Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra\u00a0O.","family":"Conde\u2010Tella","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ribeirao Preto Medical School University of Sao Paulo  Ribeirao 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