{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:15:48Z","timestamp":1773029748351,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["2020\u201002828"],"award-info":[{"award-number":["2020\u201002828"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det om H\u00e4lsa, Arbetsliv och V\u00e4lf\u00e4rd","doi-asserted-by":"publisher","award":["2024\u201001711"],"award-info":[{"award-number":["2024\u201001711"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antithrombotic therapy constitutes a critical part of stroke management, and its utilization serves as an important indicator in the assessment of stroke care. However, knowledge on how the pandemic influenced the antithrombotic utilization after stroke remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate the impact of the COVID\u201019 pandemic on the initiation of antithrombotic agents after stroke in Sweden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Using nationwide linked Swedish health registers, we conducted an interrupted time series analysis (ITSA) using generalized linear model (binomial distribution, logit link). We estimated monthly trends in the initiation of antithrombotic drugs among new stroke patients between January 2019 and April 2024, with the pandemic intervention point set in March 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>The monthly number of stroke cases declined significantly by 107 cases per month. No significant changes were observed in the total antithrombotic initiation. Antiplatelets showed a significant pre\u2010pandemic increasing trend (OR\u2009=\u20091.011 per month, 95% CI: 1.003 to 1.020), an immediate level increase at onset (OR\u2009=\u20091.150, 95% CI: 1.067 to 1.259) and a post\u2010intervention decline (OR\u2009=\u20090.991 per month, 95% CI: 0.981 to 0.998). Factor Xa inhibitors use increased post\u2010intervention (OR\u2009=\u20091.004, 95% CI: 1.002 to 1.006), while warfarin (OR\u2009=\u20090.990, 95% CI: 0.981 to 0.999) and dabigatran (OR\u2009=\u20090.991, 95% CI: 0.986 to 0.997) decreased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The COVID\u201019 pandemic had no impact on the overall use of antithrombotic agents. However, a short\u2010term increase in antiplatelet initiation and long\u2010term changes in warfarin, dabigatran, and factor Xa initiations were observed after the COVID\u201019 outbreak.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcpt.70213","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:38:03Z","timestamp":1770899883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in Antithrombotic Therapy Initiation Among Patients With Stroke Pre\u2010 and Post\u2013COVID\u201019 in Sweden\u2014An Interrupted Time Series Study"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1332-7477","authenticated-orcid":false,"given":"Salar","family":"Mousa","sequence":"first","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"},{"name":"Pharmacology and Therapeutic Department, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2517-034X","authenticated-orcid":false,"given":"Katarina","family":"Persson","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8408-9588","authenticated-orcid":false,"given":"Maria","family":"Palmetun\u2010Ekb\u00e4ck","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"},{"name":"Pharmacology and Therapeutic Department, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-5668","authenticated-orcid":false,"given":"Fredrik","family":"Nyberg","sequence":"additional","affiliation":[{"name":"School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1127-0829","authenticated-orcid":false,"given":"Huiqi","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0531-2516","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Wettermark","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology Unit, Department of Pharmacy Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8118-4988","authenticated-orcid":false,"given":"MohammadHossein","family":"Hajiebrahimi","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology Unit, Department of Pharmacy Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198\u2010018\u20100984\u20100"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(21)00252\u20100"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23733"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_2_12_6_1","volume-title":"Riksstroke \u2013 The Swedish Stroke Register","year":"2025"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gheart.2012.12.007"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)00757\u20108"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000475"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100596"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.602615"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa239"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2730"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493020972922"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.04.013"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201011\u2010882993"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.01.007"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/14034948211064656"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010020\u201010030\u20102"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2021.01571"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/23969873231204127"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000141977.18520.3b"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70016\u2010X"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030106"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106686"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00896\u20105"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005209"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005861"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.13046"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0278072"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2024.08.004"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102023\u2010082209"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0297187"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.11.068"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13944"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000068203"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010025\u201001226\u20109"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S312742"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102458\u201011\u2010450"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1294"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.2807\/esm.11.05.00626\u2010en"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010017\u20100316\u20101"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010019\u201000511\u20108"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010009\u20109350\u2010y"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.1.137"},{"key":"e_1_2_12_46_1","volume-title":"Applied Linear Statistical Models","author":"Kutner M. H.","year":"2005"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.021990"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102021\u2010319552"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.2910"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.02.011"},{"key":"e_1_2_12_51_1","volume-title":"Nationellt v\u00e5rdprogram COVID\u201019","author":"Svenska L\u00e4kares\u00e4llskapet (Swedish Medical Association)","year":"2021"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5509"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16535"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-059130"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253944"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010025\u201004492\u20103"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191912101"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.14119"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt\u20102021\u2010001784"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031007"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201002158\u20107"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010021\u201001368\u20106"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/17539447221137170"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13246"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000527373"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031659"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444679"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X1501500208"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13690\u2010025\u201001531\u20105"}],"container-title":["Basic &amp; Clinical Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcpt.70213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcpt.70213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:37:22Z","timestamp":1773027442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bcpt.70213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/bcpt.70213"],"URL":"https:\/\/doi.org\/10.1111\/bcpt.70213","archive":["Portico"],"relation":{},"ISSN":["1742-7835","1742-7843"],"issn-type":[{"value":"1742-7835","type":"print"},{"value":"1742-7843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"2025-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70213"}}