{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:19:30Z","timestamp":1777875570997,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Basic Clin Pharma Tox"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Immunosuppressive treatment helps to reduce the risk of rejection after transplantation. However, it is important to be aware of the potential toxicities that can develop after this therapy initiation. Tacrolimus is currently the calcineurin inhibitor of choice in the post\u2010transplantation immunosuppressive therapy, and its intra\u2010patient variability (Tac\u2010IPV) has been proposed in recent years as a useful biomarker in post\u2010transplant outcomes. We performed an observational retrospective study in 195 lung transplant recipients to determine the potential impact of Tac\u2010IPV as a biomarker in the development of cardiovascular toxicities and renal impairment in the post\u2010transplantation evolution. Different Tac\u2010IPV calculation measurements were shown to be statistically associated with the development of arterial hypertension\n                    <jats:italic>de novo<\/jats:italic>\n                    in the univariate analysis: the standard deviation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016 for tacrolimus C\n                    <jats:sub>min<\/jats:sub>\n                    values;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.022 for tacrolimus dose\u2010adjusted values); the coefficient of variation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021 for C\n                    <jats:sub>min<\/jats:sub>\n                    ;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.031 for dose\u2010adjusted values); and the mean absolute deviation (MAD) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.043 for C\n                    <jats:sub>min<\/jats:sub>\n                    ;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.033 for dose\u2010adjusted values). Those patients with a MAD\u2009\u2265\u200916.47% had a higher risk of renal impairment (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.045). In our study, different Tac\u2010IPV measures were associated with arterial hypertension in lung transplantation follow\u2010up. Patients with a high Tac\u2010IPV, using the MAD as a measurement, showed a higher risk for renal impairment. No other statistically significant associations were found for the other studied events.\n                  <\/jats:p>","DOI":"10.1111\/bcpt.70229","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:33:37Z","timestamp":1774528417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Tacrolimus Intra\u2010Patient Variability on Toxicity Development Among Lung Transplant Recipients"],"prefix":"10.1111","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7989-6951","authenticated-orcid":false,"given":"Rita","family":"Nogueiras\u2010\u00c1lvarez","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Osakidetza\u2010Basque Health Service, Galdakao\u2010Usansolo University Hospital  Galdakao Bizkaia 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