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We employed validated disproportionality metrics including the reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN) and multi\u2010item gamma Poisson shrinker (MGPS) to detect significant drug\u2010event associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After removing duplicates, a total of 42\u2009583 cases of patients treated with antiparkinsonian drugs were included in the FAERS database. Dopamine receptor agonists exhibited the most extensive range of cardiac adverse events. Monoamine oxidase B inhibitors displayed the second broadest range of toxicity. As for catechol\u2010O\u2010methyltransferase inhibitors, a total of six signals were detected in entacapone. Four signals were detected for amantadine, while no signals were identified for levodopa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the cardiovascular adverse reactions associated with Parkinson's treatment drugs. These findings underscore the importance of monitoring and evaluating the cardiovascular safety of antiparkinsonian medications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcpt.70242","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:06:19Z","timestamp":1777878379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Cardiovascular Safety of Antiparkinsonian Drugs\u2014Analysis of Signals in the FDA Adverse Event Report System Database"],"prefix":"10.1111","volume":"138","author":[{"given":"Xin","family":"Mu","sequence":"first","affiliation":[{"name":"Department of Neurology Chengdu First People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2318-3132","authenticated-orcid":false,"given":"Yanfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Affiliated Hospital of Yan'an University  Yan'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyao","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Geriatric Neurology Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neurology Chongqing University FuLing Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-7549","authenticated-orcid":false,"given":"Pingping","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Geriatric Neurology Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.151179"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359105315616471"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.3299"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(21)00219\u20102"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.09.014"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1463"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(04)15945\u2010X"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010015\u20100293\u20104"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr.v8i6.2599"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(18)30608\u20109"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.70159"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.17.1.19214"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40290\u2010024\u201000530\u20101"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360\u2010025\u201000911\u20105"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.11.018"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102016\u2010313642"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2004.04.001"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/834796"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2.3.393"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.04.007"},{"issue":"1","key":"e_1_2_13_22_1","first-page":"S14","article-title":"Dopamine and Dopamine Receptor Agonists in Cardiovascular Therapy","volume":"18","author":"Murphy M. 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